Is Benzophenone-8 safe in cosmetics?
Benzophenone-8 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: restricted.
Moderate
Cosmetic Ingredient
Benzophenone-8
Also known as: Methanone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-, Benzophenone, 2,2'-dihydroxy-4-methoxy-, Advastab 47, BRN 2055461, Cyasorb UV 24 (+10 more)
INCI: BENZOPHENONE-8
Benzophenone-8 (CAS 131-53-3) is a cosmetic cosmetic ingredient functioning as UV absorber, sunscreen agent. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 131-53-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Benzophenone-8 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
UV absorber, sunscreen agent
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Was listed as OTC sunscreen active up to 3% (21 CFR 352.10). FDA 2019 proposed rule excluded BP-8 from final monograph due to insufficient data for GRASE determination.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Benzophenone-8.
Calculate MoS for your specific formulation with the MoS Calculator.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: ERα, ERβ, AR
LOEC: 0.1 µM
EU status: not approved as UV filter; not_listed
agonist (ERα, ERβ); antagonist (AR)
Dose-Response Data Points
| Endpoint | Target | Value | Direction |
|---|---|---|---|
| Cell proliferation (BrdU), ERE-Luc, pS2 expression | ERa | EC50/IC50: Active >=10^-6 M (proliferation); >=10^-7 M (ERE-Luc); LOEC: 0.1 uM (ERE-Luc); NOEC: 0.01 uM mixed | agonist |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 3%.
JPKR Japan/Korea Cosmetics
Korea (Restricted): max 3%
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_pollution
{"cas_number": "131-53-3", "ingredient_class": "blue_light_filter", "primary_mechanism": "film_forming_barrier", "pollution_types_targeted": "UV_A/UV_B", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
UV stabilizer
Expert Verdict
Expert safety assessment and concern-level summary for Benzophenone-8.
Regulatory Flags
potential-allergen
Known Synonyms
Methanone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-
Benzophenone, 2,2'-dihydroxy-4-methoxy-
Advastab 47
BRN 2055461
Cyasorb UV 24
Cyasorb UV 24 Light Absorber
Dioxibenzonum
Dioxybenzon
EINECS 205-026-8
NSC 56769
Spectra-sorb UV 24
Dioxibenzona
Dioxybenzonum
UNII-B762XZ551X
Dioxybenzone
Chemical Function
UV stabilizer
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; consumer_product; Substances in Products - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Benzophenone-8 allowed in the EU?
Benzophenone-8 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzophenone-8 do in cosmetics?
Benzophenone-8 functions as: UV absorber, sunscreen agent. It is classified as a cosmetic ingredient in our database. CAS number: 131-53-3.
Is Benzophenone-8 used outside cosmetics?
Benzophenone-8 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Benzophenone-8 have different safety status in cosmetics vs industrial chemicals?
Benzophenone-8 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Compliance Tools
Check Benzophenone-8 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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