What is the NOAEL for 2,2'-Dihydroxy-4-methoxybenzophenone?
2,2'-Dihydroxy-4-methoxybenzophenone has 4 NOAEL studies in the database. The lowest reported value is B762XZ551X UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,2'-Dihydroxy-4-methoxybenzophenone
Also known as: Methanone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-, Benzophenone, 2,2'-dihydroxy-4-methoxy-, Advastab 47, BRN 2055461, Cyasorb UV 24 (+10 more)
CAS 131-53-3
2,2'-Dihydroxy-4-methoxybenzophenone (CAS 131-53-3) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2,2'-Dihydroxy-4-methoxybenzophenone is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
2,2'-Dihydroxy-4-methoxybenzophenone
CAS Number
131-53-3
DTXSID
DTXSID3022403
Molecular Formula
C14H12O4
InChI Key
MEZZCSHVIGVWFI-UHFFFAOYSA-N
Monoisotopic Mass
244.073559
Synonyms
Methanone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-Benzophenone, 2,2'-dihydroxy-4-methoxy-Advastab 47BRN 2055461Cyasorb UV 24Cyasorb UV 24 Light AbsorberDioxibenzonumDioxybenzonEINECS 205-026-8NSC 56769Spectra-sorb UV 24Dioxibenzona
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
UV stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| B762XZ551X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B762XZ551X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B762XZ551X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B762XZ551X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dioxybenzone | 205-026-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
UV Filter
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
DIOXYBENZONE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include 2,2'-Dihydroxy-4-methoxybenzophenone?
2,2'-Dihydroxy-4-methoxybenzophenone appears on 3 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical, Canada; consumer_product; Substances in Products - Canada (4/2014). Source: EPA CPDat.
Is 2,2'-Dihydroxy-4-methoxybenzophenone used in cosmetics?
Yes, 2,2'-Dihydroxy-4-methoxybenzophenone is also indexed as a cosmetic ingredient under the name Benzophenone-8. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,2'-Dihydroxy-4-methoxybenzophenone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,2'-Dihydroxy-4-methoxybenzophenone have different safety status in cosmetics vs industrial chemicals?
2,2'-Dihydroxy-4-methoxybenzophenone is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Is 2,2'-Dihydroxy-4-methoxybenzophenone used outside industrial chemicals?
2,2'-Dihydroxy-4-methoxybenzophenone also appears in cosmetics, pharmaceutical databases.