Is Asiatic Acid — Structured Cosmetic Ingredient safe in cosmetics?
Asiatic Acid — Structured Cosmetic Ingredient has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Asiatic Acid — Structured Cosmetic Ingredient
Also known as: Urs-12en-28-oic acid, 2,3,23-trihydroxy-, (2alpha, 3beta, 4alpha)-
INCI: ASIATIC ACID
Asiatic Acid — Structured Cosmetic Ingredient (CAS 464-92-6) is a cosmetic colorant functioning as Colorant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 464-92-6 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
OTC drug. No specific restrictions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Asiatic Acid — Structured Cosmetic Ingredient.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Asiatic Acid — Structured Cosmetic Ingredient, relevant to systemic exposure and MoS calculations.
Absorption %
4-10%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
488.7 Da
Log P
5.5
Systemic Absorption
minimal
Topical Bioavailability
2-8%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: Molecules 2012
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
3 property records from structured ingredient metadata.
acne
{"cas_number": "464-92-6", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "collagen-boosting, barrier-repair", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Yes", "elastin_protection": "Mild", "wrinkle_reduction_pct": "12-22", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JAA…
dermal_absorption
{"molecular_weight_da": "488.7", "log_p_value": "5.5", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum/epidermis", "absorption_pct": "4-10", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "2-8", "safety_margin_factor": "low",…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Stabilizing agent
Expert Verdict
Expert safety assessment and concern-level summary for Asiatic Acid — Structured Cosmetic Ingredient.
Regulatory Flags
Allergen
Known Synonyms
Urs-12en-28-oic acid, 2,3,23-trihydroxy-, (2alpha, 3beta, 4alpha)-
Chemical Function
Softener and conditioner
Stabilizing agent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ASIATIC ACID
ChEMBL ID
CHEMBL404313
Frequently Asked Questions
Is Asiatic Acid — Structured Cosmetic Ingredient allowed in the EU?
Asiatic Acid — Structured Cosmetic Ingredient EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Asiatic Acid — Structured Cosmetic Ingredient do in cosmetics?
Asiatic Acid — Structured Cosmetic Ingredient functions as: Colorant. It is classified as a Colorant in our database. CAS number: 464-92-6.
Is Asiatic Acid — Structured Cosmetic Ingredient used outside cosmetics?
Asiatic Acid — Structured Cosmetic Ingredient also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Asiatic Acid — Structured Cosmetic Ingredient compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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