Is Asiatic Acid safe in cosmetics?
Asiatic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Asiatic Acid
Also known as: Urs-12en-28-oic acid, 2,3,23-trihydroxy-, (2alpha, 3beta, 4alpha)-
INCI: ASIATIC ACID
Asiatic Acid (CAS 464-92-6) is a cosmetic active ingredient functioning as skin-conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 464-92-6 →
Auto-generated CPSR Part A draft with source citations
Function
skin-conditioning
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restrictions on cosmetic use of asiatic acid. Not classified as an OTC monograph ingredient; not a UV filter. CIR Expert Panel (2015 tentative report) reviewed 9 Centella asiatica-derived ingredients but did not individually assess asiatic acid as a standalone INCI. The Panel concluded insufficient data were available for most Centella-derived extracts to support a safety determination. No VCRP-specific usage concentration data for isolated asiatic acid was identified. No CIR final opinion for the isolated ingredient exists; ingredient remains without a standalone US CIR safety determination.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Asiatic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Asiatic Acid, relevant to systemic exposure and MoS calculations.
Absorption %
4-10%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
488.7 Da
Log P
5.5
Systemic Absorption
minimal
Topical Bioavailability
2-8%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: Molecules 2012
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
3 property records from structured ingredient metadata.
acne
{"cas_number": "464-92-6", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "collagen-boosting, barrier-repair", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Yes", "elastin_protection": "Mild", "wrinkle_reduction_pct": "12-22", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JAA…
dermal_absorption
{"molecular_weight_da": "488.7", "log_p_value": "5.5", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum/epidermis", "absorption_pct": "4-10", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "2-8", "safety_margin_factor": "low",…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Stabilizing agent
Expert Verdict
Expert safety assessment and concern-level summary for Asiatic Acid.
Regulatory Flags
no-sccs-opinion
cir-insufficient-data
poor-dermal-absorption
weak-sensitizer
data-gap-absorption
no-mos-calculation
oral-hepatotoxicity-reports
reproductive-toxicity-oral-extract
Known Synonyms
Urs-12en-28-oic acid, 2,3,23-trihydroxy-, (2alpha, 3beta, 4alpha)-
Chemical Function
Softener and conditioner
Stabilizing agent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ASIATIC ACID
ChEMBL ID
CHEMBL404313
Frequently Asked Questions
Is Asiatic Acid allowed in the EU?
Asiatic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Asiatic Acid do in cosmetics?
Asiatic Acid functions as: skin-conditioning. It is classified as a Active Ingredient in our database. CAS number: 464-92-6.
Is Asiatic Acid used outside cosmetics?
Asiatic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Asiatic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Asiatic Acid — Structured Cosmetic Ingredient
Moderate
Chemical family
Colorant
ASPARAGOPSIS ARMATA EXTRACT
Good
Browse nearby
Skin Protecting
ASPARAGUS OFFICINALIS EXTRACT
Good
Browse nearby
Skin Conditioning
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