NOAEL Studies Cosmetic Ingredient

ANILINE NOAEL Studies

CAS: 62-53-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 NSRL AB100 ug/day - - 1990-01-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"100","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 NSRL AB100 ug/day - - 1990-01-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"100","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 NSRL AB100 ug/day - - 1990-01-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"100","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABcancer listing type - - 1990-01-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"100","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABcancer listing type - - 1990-01-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"100","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABcancer listing type - - 1990-01-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"100","source_table":"prop65_listings"}
EPA_IRIS_iris_rfc_systems.csv 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA_IRIS_iris_rfc_systems.csv NOAEL (HEC) =3.4 mg/m^3 - inhalation chronic IRIS chronic inhalation RfC system PoD row_hash=0a58c00bea46aa0a; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 3.4 mg/m^3; system=Hematologic; basis=Methemoglobin increase, spleen toxicity; point_of_departure=NOAEL (HEC): 3.4 mg/m^3; composite_uf=3000; confidence=Low; dtxsid=DTXSID8020090; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=350; rfc_last_updated=11/01/1990; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0350_summary.pdf
EPA_IRIS_iris_rfc_systems.csv RfC =0.001 mg/m^3 - inhalation chronic IRIS chronic inhalation RfC system row_hash=7c2bb3db59adf4ba; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=1e-3; system=Hematologic; basis=Methemoglobin increase, spleen toxicity; point_of_departure=NOAEL (HEC): 3.4 mg/m^3; composite_uf=3000; confidence=Low; dtxsid=DTXSID8020090; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=350; rfc_last_updated=11/01/1990; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0350_summary.pdf
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 2A IARC group - - 2020 IARC Monographs {"additional_info":"volume_publication_year=2021","evaluation_year":2020,"source_table":"iarc_classifications","volume":"27, Sup 7, 127"}
NTP_ICE_acute_inhalation 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 3.1937 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4319; Record_ID=acute_inhalation_1802; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3.1937; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_acute_inhalation LC50 0.9516 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4320; Record_ID=acute_inhalation_1803; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.9516; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_acute_inhalation LC50 1.8195 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4322; Record_ID=acute_inhalation_1656; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.8195; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15333/7/3/3/?documentUUID=ceeeb69d-9400-4db8-9bed-e2e29898a18e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=8490; Record_ID=cancer_2850; Data_Type=WOE; Formulation_Name=Aniline; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/45; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_cancer Oral slope factor 0.0057 mg/kg bw/day - Oral - WOE; IRIS Carcinogenicity sheet=Data; excel_row=8486; Record_ID=cancer_2851; Data_Type=WOE; Formulation_Name=Aniline; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=5.7000000000000002E-3; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0350_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization 46 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 550.8 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2211; Record_ID=skin_sensitization_invitro_544; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=550.79999999999995; Reported_Response_Unit=ug/mL; Response=550.8; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization CD86, EC120 70.974 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; mMUSST sheet=Data_invitro; excel_row=7776; Record_ID=skin_sensitization_invitro_1874; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=mMUSST; Endpoint=CD86, EC120; Reported_Response=762.1; Reported_Response_Unit=uM; Conversion_Factor_Value=93.129; Conversion_Factor_Source=EPA Dashboard; Converted_Response=70.974; Converted_Response_Unit=ug/mL; Response=70.974; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization CD86, EC150 927.9 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2213; Record_ID=skin_sensitization_invitro_544; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=927.9; Reported_Response_Unit=ug/mL; Response=927.9; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization CD86, EC150 280 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3719; Record_ID=skin_sensitization_invitro_849; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=280; Reported_Response_Unit=ug/mL; Response=280; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization CD86, EC150 31.003 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8195; Record_ID=skin_sensitization_invitro_2218; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=332.9; Reported_Response_Unit=uM; Conversion_Factor_Value=93.129; Conversion_Factor_Source=EPA Dashboard; Converted_Response=31.003; Converted_Response_Unit=ug/mL; Response=31.003; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization CD86, EC150 62.5 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8626; Record_ID=skin_sensitization_invitro_2383; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=62.5; Reported_Response_Unit=ug/mL; Response=62.5; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization CV70 >200 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8621; Record_ID=skin_sensitization_invitro_2383; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization CV75 930 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2215; Record_ID=skin_sensitization_invitro_544; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=h-CLAT; Endpoint=CV75; Reported_Response=930; Reported_Response_Unit=ug/mL; Response=930; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization CV75 403.2 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3721; Record_ID=skin_sensitization_invitro_849; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=h-CLAT; Endpoint=CV75; Reported_Response=403.2; Reported_Response_Unit=ug/mL; Response=403.2; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 3.571 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9155; Record_ID=skin_sensitization_invivo_2025; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=3.571; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Concentration, one positive response 2.857 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9151; Record_ID=skin_sensitization_invivo_2025; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=2.857; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Depletion Cys -1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1428; Record_ID=skin_sensitization_invitro_381; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-1; Reported_Response_Unit=%; Response=-1; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Depletion Cys 0.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1432; Record_ID=skin_sensitization_invitro_382; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Depletion Lys 2.4 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1427; Record_ID=skin_sensitization_invitro_381; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=2.4; Reported_Response_Unit=%; Response=2.4; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Depletion Lys 0 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1431; Record_ID=skin_sensitization_invitro_382; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Depletion Lys 9.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1435; Record_ID=skin_sensitization_invitro_383; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=9.6999999999999993; Reported_Response_Unit=%; Response=9.7; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Depletion Lys + Cys 0.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1429; Record_ID=skin_sensitization_invitro_381; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.7; Reported_Response_Unit=%; Response=0.7; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Depletion Lys + Cys 0.15 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1433; Record_ID=skin_sensitization_invitro_382; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.15; Reported_Response_Unit=%; Response=0.15; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Depletion Lys + Cys 4.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1437; Record_ID=skin_sensitization_invitro_383; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=4.9000000000000004; Reported_Response_Unit=%; Response=4.9; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC1.5 2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6330; Record_ID=skin_sensitization_invitro_1478; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=2; Reported_Response_Unit=uM; Response=2; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 89 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13245; Record_ID=skin_sensitization_invivo_3318; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=89; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 50 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13258; Record_ID=skin_sensitization_invivo_3336; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=50; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 13.25 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13270; Record_ID=skin_sensitization_invivo_3352; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=13.25; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 16.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13291; Record_ID=skin_sensitization_invivo_3390; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=16.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 89 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13245; Record_ID=skin_sensitization_invivo_3318; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=89; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 50 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13258; Record_ID=skin_sensitization_invivo_3336; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=50; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 13.25 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13270; Record_ID=skin_sensitization_invivo_3352; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=13.25; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 16.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13291; Record_ID=skin_sensitization_invivo_3390; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=16.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 89 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13245; Record_ID=skin_sensitization_invivo_3318; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=89; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 50 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13258; Record_ID=skin_sensitization_invivo_3336; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=50; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 13.25 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13270; Record_ID=skin_sensitization_invivo_3352; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=13.25; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 16.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13291; Record_ID=skin_sensitization_invivo_3390; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=16.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 89 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13245; Record_ID=skin_sensitization_invivo_3318; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=89; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 50 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13258; Record_ID=skin_sensitization_invivo_3336; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=50; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 13.25 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13270; Record_ID=skin_sensitization_invivo_3352; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=13.25; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization EC3 16.6 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13291; Record_ID=skin_sensitization_invivo_3390; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LLNA; Endpoint=EC3; Response=16.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1991; Not available; 10.3109/15376519109036523; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization IC50 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6255; Record_ID=skin_sensitization_invitro_1477; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization IC50 >2400 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7649; Record_ID=skin_sensitization_invitro_1818; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2400; Reported_Response_Unit=uM; Response=2400; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Imax 1.38 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6259; Record_ID=skin_sensitization_invitro_1477; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.38; Reported_Response_Unit=Unitless; Response=1.38; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Imax 1.7 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=6261; Record_ID=skin_sensitization_invitro_1478; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.7; Reported_Response_Unit=Unitless; Response=1.7; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Imax 1.035 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7552; Record_ID=skin_sensitization_invitro_1818; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=LuSens; Endpoint=Imax; Reported_Response=1.035314854; Reported_Response_Unit=Unitless; Response=1.035; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Incidence of positive responses 28 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9147; Record_ID=skin_sensitization_invivo_2025; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=28; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Induction dose per skin area 12410 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9145; Record_ID=skin_sensitization_invivo_2025; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=12410; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 2217 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9157; Record_ID=skin_sensitization_invivo_2025; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2217; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 1773 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9153; Record_ID=skin_sensitization_invivo_2025; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1773; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
NTP_ICE_skin_sensitization Relative reliability score 1 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9159; Record_ID=skin_sensitization_invivo_2025; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8020090; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020090; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020090
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =49516.7 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=DOE Protective Action Criteria:15512280:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b34d398260a896f3b92b68ad571354b
ToxValDB_ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =25 mg/kg bw/day Rat oral acute; 0.25 days acute LONG_REF=EPA/OTS Doc.#40-8476328:52 p. SOCMA Methemoglobin Inducing Potential of Various Substituted Anilines with Cover Letter Dated 121984 2000; TITLE=Methemoglobin Inducing Potential of Various Substituted Anilines with Cover Letter Dated 121984; AUTHOR=SOCMA; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102343; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Biochemistry: Methemoglobin; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX:15597039:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5060bd42e5ea9d4516f168bfedc6c2fd
ToxValDB_ECOTOX LOEL =560 mg/kg bw/day Mouse oral short-term (developmental); 8 days reproduction developmental LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15612735:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=2a2b5c498a2b514ba7fd592d931549e8
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA BMDL (10) ~29 mg/kg bw/day Rat oral chronic; 104 weeks chronic LONG_REF=EFSA AFC (2007). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the food colour Red 2G (E128) based on a request from the Commission related to the re-evaluation of all permitted food additives. doi:10.2903/j.efsa.2007.515.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the food colour Red 2G (E128) based on a request from the Commission related to the re-evaluation of all permitted food additives; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2007.515; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15614253:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38ee5d4331afd6bd1139edc07218d8de
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =7.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629849:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5bc7db51515465fdabde8d9c3bfd4e44
ToxValDB_HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =38.0898 mg/m3 Rat inhalation short-term; 2 weeks short-term LONG_REF=Burgess, B.A. et al., The Toxicologist 4, p. 64 [A] (1984).; AUTHOR=Burgess, B.A. et al; EXTERNAL_SOURCE_ID=61998; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639260:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_315eb696b864c6188f58dd846a73de0e
ToxValDB_Health_Canada 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Health_Canada LOAEL =7.2 mg/kg bw/day Rat oral chronic; 104 weeks chronic LONG_REF=PSL1: HC, 1996a (based on CIIT, 1982); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=increased splenic hemosiderin deposition, extramedullary hematopoiesis, and congestion in male rats; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=Health Canada:15637515:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9cf63ef2e01ad31acfdd5ad0e0b3d6d5
ToxValDB_Health_Canada TDI =0.0072 mg/kg bw/day Human oral chronic; 104 weeks Toxicity Value LONG_REF=PSL1: HC, 1996a (based on CIIT, 1982); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=LOAEL = increased splenic hemosiderin deposition, extramedullary hematopoiesis, and congestion in male rats|NOAEL = methemoglobin in female rats; STUDY_GROUP=Health Canada:15637369:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a8e56bdffd52ea0f269e5029f1c3c14c
ToxValDB_IRIS 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_IRIS LOAEL =64.7 mg/m3 Rat inhalation short-term; 2 weeks short-term LONG_REF=duPont deNemours and Company, Inc. 1982. Subacute inhalation toxicity study of aniline in rats. OTS No. 878220240. Fiche No. 0215025. Available from EPA. Write to FOI, EPA, Washington, DC 20460; TITLE=Subacute inhalation toxicity study of aniline in rats; AUTHOR=duPont deNemours and Company, Inc; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a579a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=350; TOXICOLOGICAL_EFFECT=Mild spleen toxicity 2-Week; STUDY_GROUP=IRIS_dup_IRIS Summary_15644296_15644297_15644298:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e8ec32eb5192a1ec05ab28e4440e12b5
ToxValDB_IRIS LOAEL (ADJ) =11.6 mg/m3 Rat inhalation short-term; 2 weeks short-term LONG_REF=duPont deNemours and Company, Inc. 1982. Subacute inhalation toxicity study of aniline in rats. OTS No. 878220240. Fiche No. 0215025. Available from EPA. Write to FOI, EPA, Washington, DC 20460; TITLE=Subacute inhalation toxicity study of aniline in rats; AUTHOR=duPont deNemours and Company, Inc; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a579a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=350; TOXICOLOGICAL_EFFECT=Mild spleen toxicity 2-Week; STUDY_GROUP=IRIS_dup_IRIS Summary_15644296_15644297_15644298:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7da48adcbc2f863d092b8d48b314af2d
ToxValDB_IRIS NOAEL =19 mg/m3 Rat inhalation chronic; 26 weeks chronic LONG_REF=Oberst F.W., E. Hackley, C. Comstock. 1956. Chronic toxicity of aniline vapor (5 ppm) by inhalation. Arch. Ind. Health. 13: 379-384.; TITLE=Chronic toxicity of aniline vapor (5 ppm) by inhalation; AUTHOR=Oberst F.W., E. Hackley, C. Comstock; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a579a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=350; TOXICOLOGICAL_EFFECT=methemoglobin increase, spleen toxicity; STUDY_GROUP=IRIS_dup_IRIS Summary_15644292_15644293_15644294:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ae06aec5365d3dd46c7015128006c85d
ToxValDB_IRIS NOAEL (ADJ) =3.4 mg/m3 Rat inhalation chronic; 26 weeks chronic LONG_REF=Oberst F.W., E. Hackley, C. Comstock. 1956. Chronic toxicity of aniline vapor (5 ppm) by inhalation. Arch. Ind. Health. 13: 379-384.; TITLE=Chronic toxicity of aniline vapor (5 ppm) by inhalation; AUTHOR=Oberst F.W., E. Hackley, C. Comstock; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a579a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=350; TOXICOLOGICAL_EFFECT=methemoglobin increase, spleen toxicity; STUDY_GROUP=IRIS_dup_IRIS Summary_15644292_15644293_15644294:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_11938d8f92edaae98d4cdf1e77d05230
ToxValDB_IRIS RfC =0.001 mg/m3 Human inhalation - Toxicity Value LONG_REF=Oberst F.W., E. Hackley, C. Comstock. 1956. Chronic toxicity of aniline vapor (5 ppm) by inhalation. Arch. Ind. Health. 13: 379-384.; TITLE=Chronic toxicity of aniline vapor (5 ppm) by inhalation; AUTHOR=Oberst F.W., E. Hackley, C. Comstock; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a579a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=350; TOXICOLOGICAL_EFFECT=Methemoglobin increase, spleen toxicity in male/female rats; STUDY_GROUP=IRIS:15644295:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1db29ffa77f92677ab2ed6da457aacb8
ToxValDB_PPRTV_(CPHEA) 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) LOAEL =7 mg/kg bw/day Rat oral chronic; 104 weeks chronic LONG_REF=CIIT 1982; AUTHOR=CIIT; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b33f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1572; TOXICOLOGICAL_EFFECT=Immune, Hematologic; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=PPRTV (CPHEA):15653863:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_626ddd70488ff751b665a7dfb4ab687b
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Pennsylvania_DEP_ToxValues RfD =0.007 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15649805:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c347eedb504593695df9853e9eece4f0
ToxValDB_RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_RSL RfC =0.01 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663167:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b40360154dd8f311daeeecec06695c9
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier SIR7XX2F1K UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"SIR7XX2F1K"}
openFDA substances FDA UNII substance identifier SIR7XX2F1K UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"SIR7XX2F1K"}
openFDA substances FDA UNII substance identifier SIR7XX2F1K UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"SIR7XX2F1K"}
openFDA substances FDA UNII substance identifier SIR7XX2F1K UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"SIR7XX2F1K"}