Is Aminomethyl Propanol safe in cosmetics?
Aminomethyl Propanol has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Aminomethyl Propanol
Also known as: 2-Amino-2-methyl-1-propanol, beta-Aminoisobutanol, BRN 0505979, Caswell No. 037, EINECS 204-709-8 (+3 more)
INCI: AMINOMETHYL PROPANOL
Aminomethyl Propanol (CAS 124-68-5) is a cosmetic cosmetic ingredient functioning as pH Adjuster. NOAEL 0.73 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 7%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 124-68-5 →
Auto-generated CPSR Part A draft with source citations
Function
pH Adjuster
Safety Rating
GOOD
Regulatory Status
EU EU Status
restricted
EU Max Conc.
7%
US US Status
permitted
US Notes
CIR: S - JACT 9(2):203-228, 1990
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aminomethyl Propanol.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes. The substance is severely irritating to the skin. The aerosol is irritating to the respiratory tract.
Long-term Exposure Effects
Ingestion may cause effects on the liver.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Aminomethyl Propanol across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Irrit. 2; Eye Irrit. 2; Aquatic Chronic 3
Hazard Statements
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
8 property records from structured ingredient metadata.
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "2.0", "typical_concentration_pct": "0.5", "product_type": "Serum", "function_at_concentration": "pH adjuster, neutralizer", "source": "CIR Safety Assessment"}
deodorant
{"cas_number": "124-68-5", "ingredient_class": "other", "mechanism_of_action": "pH_modification", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "0", "odor_reduction_pct": "0", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies", "astringency_level…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "14-28", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low-moderate toxicity", "freshwater_toxicity": "moderate at high conc", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "…
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "2.0", "adult_max_concentration_pct": "2.0", "pediatric_dermal_absorption_factor": "moderate", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "eye_irritation_risk": "low", "diaper_ar…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
self_tanning
{"cas_number": "124-68-5", "ingredient_class": "other", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "AGE_formation_concern": "no…
supply_chain
{"primary_producing_countries": "USA, Germany, China", "secondary_producing_countries": "France, Japan", "raw_material_origin": "synthetic", "agricultural_crop_or_wild_harvested": "petrochemical", "cultivation_climate_required": "industrial", "harvest_season": "continuous", "annual_global_production_tonnes": "28000", "market_share_top_producer_pct": "52", "supply_chain_length": "1_intermediary", "…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Biocide
Catalyst
Corrosion inhibitor
Degradant/impurity
Deodorizer
Dispersing agent
Emulsifier
Preservative
Processing aids not otherwise specified
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Aminomethyl Propanol.
Regulatory Flags
EU Restricted
eu_children_restricted
Known Synonyms
2-Amino-2-methyl-1-propanol
beta-Aminoisobutanol
BRN 0505979
Caswell No. 037
EINECS 204-709-8
EPA Pesticide Chemical Code 005801
2-Methyl-2-aminopropanol-1
UNII-LU49E6626Q
Chemical Function
pH regulating agent
Solvent
Binder
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
children; Europe; Personal care
children; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DEANOL
ChEMBL ID
CHEMBL122588
Frequently Asked Questions
Is Aminomethyl Propanol allowed in the EU?
Aminomethyl Propanol EU regulatory status: restricted. Maximum allowed concentration: 7%. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminomethyl Propanol do in cosmetics?
Aminomethyl Propanol functions as: pH Adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 124-68-5.
Is Aminomethyl Propanol used outside cosmetics?
Aminomethyl Propanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Aminomethyl Propanol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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