Is Allyl Phenoxyacetate safe in cosmetics?
Allyl Phenoxyacetate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Allyl Phenoxyacetate
Also known as: Acetate p.a., Acetate pa, 2-Propenyl phenoxyacetate, Acetic acid, phenoxy-, 2-propenyl ester, Acetic acid, 2-phenoxy-, 2-propen-1-yl ester (+5 more)
INCI: ALLYL PHENOXYACETATE
Allyl Phenoxyacetate (CAS 7493-74-5) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 7493-74-5 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
prop-2-enyl 2-phenoxyacetate
InChIKey
VUFZVGQUAVDKMC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not specifically restricted by FDA; IFRA standards apply voluntarily
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Allyl Phenoxyacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Allyl Phenoxyacetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Allyl Phenoxyacetate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
0.61%
DPRA Lys %
4.08%
KeratinoSens IC50
2000 µM
hCLAT CV75
1000 µg/mL
LLNA EC3
3.1%
NESIL
648 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Human: positive
Source: LLNA: personal communication by RIFM (RIFM DB #52909); DPRA: Hoffmann et al., 2018; KS: Natsch et al. 2015 [DOI:10.1093/toxsci/kfu229]; hCLAT: No reference provided in NICEATM database; HPPT: [229] Kligman AM (1974): Report to RIFM, 19 November, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 108 | 0 | 709 | 709 | non-sensitizer |
| HMT | - | 0 | 648 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
India: Restricted
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Restriction/Specification. Effective: 2021-02-10.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | 0.054% | 7a (Deodorant – not spray) | 0.41% |
| 2 (Body spray) | 0.016% | 7b (Deodorant spray) | 0.41% |
| 3 (Body cream) | 0.21% | 8 (Face cream) | 0.025% |
| 4 (Fine fragrance) | 0.3% | 9 (Soap) | 0.59% |
| 5a (Body lotion) | 0.076% | 10a (Household – non-spray) | 0.59% |
| 5b (Face cream leave-on) | 0.076% | 10b (Household – spray) | 1.7% |
| 5c (Hand cream) | 0.076% | 11a (Intimate – leave-on) | 0.025% |
| 5d (Baby cream) | 0.025% | 11b (Intimate – rinse) | 0.025% |
| 6 (Mouthwash) | 0.18% | 12 (Not for consumer exposure) | 52% |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
18
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ALLYL PHENOXYACETATE | 1996 | No safety concern at current levels of intake when used as a flavouring agent | TRS 868-JECFA 46/28
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Allyl Phenoxyacetate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
eu_cosing_listed
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Allyl Phenoxyacetate by CAS number or substance name.
Studies
1
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
50 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Acetate p.a.
Acetate pa
2-Propenyl phenoxyacetate
Acetic acid, phenoxy-, 2-propenyl ester
Acetic acid, 2-phenoxy-, 2-propen-1-yl ester
BRN 2102680
EINECS 231-335-2
FEMA No. 2038
NSC 408892
UNII-Q3P8UAF9WE
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Allyl Phenoxyacetate allowed in the EU?
Allyl Phenoxyacetate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Allyl Phenoxyacetate do in cosmetics?
Allyl Phenoxyacetate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 7493-74-5.
What is the NOAEL for Allyl Phenoxyacetate?
The NOAEL (No Observed Adverse Effect Level) for Allyl Phenoxyacetate is =50 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Allyl Phenoxyacetate used outside cosmetics?
Allyl Phenoxyacetate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Allyl Phenoxyacetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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