What is the NOAEL for Allyl phenoxyacetate?
Allyl phenoxyacetate has 31 NOAEL studies in the database. The lowest reported value is 2.47 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Allyl phenoxyacetate
Also known as: Acetate p.a., Acetate pa, 2-Propenyl phenoxyacetate, Acetic acid, phenoxy-, 2-propenyl ester, Acetic acid, 2-phenoxy-, 2-propen-1-yl ester (+5 more)
CAS 7493-74-5
Allyl phenoxyacetate (CAS 7493-74-5) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
31
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Allyl phenoxyacetate
CAS Number
7493-74-5
DTXSID
DTXSID3064722
Molecular Formula
C11H12O3
InChI Key
VUFZVGQUAVDKMC-UHFFFAOYSA-N
Monoisotopic Mass
192.078644
Synonyms
Acetate p.a.Acetate pa2-Propenyl phenoxyacetateAcetic acid, phenoxy-, 2-propenyl esterAcetic acid, 2-phenoxy-, 2-propen-1-yl esterBRN 2102680EINECS 231-335-2FEMA No. 2038NSC 408892UNII-Q3P8UAF9WE
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 31 of 31 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| >1000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =2.47 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 404.9 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| Q3P8UAF9WE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q3P8UAF9WE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q3P8UAF9WE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q3P8UAF9WE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.85 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 648 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =150 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 55.4 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 56 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 72 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 72.7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 77 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 91.7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 91.9 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 94.3 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 94.7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 95.46 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 96.3 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 96.39 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 96.82 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 99.66 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 102.14 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 105.57 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
Showing 31 of 31 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Allyl phenoxyacetate | 231-335-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Allyl phenoxyacetate?
Allyl phenoxyacetate appears on 5 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is Allyl phenoxyacetate used in cosmetics?
Yes, Allyl phenoxyacetate is also indexed as a cosmetic ingredient under the name Allyl Phenoxyacetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Allyl phenoxyacetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Allyl phenoxyacetate used outside industrial chemicals?
Allyl phenoxyacetate also appears in cosmetics, cannabis databases.