Is Allyl Methacrylate safe in cosmetics?
Allyl Methacrylate has a safety rating of "POOR" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Allyl Methacrylate
Also known as: 2-Propenoic acid, 2-methyl-, 2-propenyl ester, 2-Propenoic acid, 2-methyl-, 2-propen-1-yl ester, Ageflex AMA, BRN 1747406, EINECS 202-473-0 (+4 more)
INCI: ALLYL METHACRYLATE
Allyl Methacrylate (CAS 96-05-9) is a cosmetic cosmetic ingredient functioning as Cross-linking monomer; used as a building block for polymers in cosmetics (film. NOAEL 6 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 96-05-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Allyl Methacrylate is classified GHS Danger (H226, H302, H311, H312, H330, H331, H373, H400) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Cross-linking monomer; used as a building block for polymers in cosmetics (film forming, viscosity controlling)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
prop-2-enyl 2-methylprop-2-enoate
InChIKey
FBCQUCJYYPMKRO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not specifically regulated by FDA for cosmetics; used industrially as a monomer
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Allyl Methacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Allyl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =25 mg/kg bw/day | dermal | Rabbit | acute | ToxValDB_ECHA_IUCLID |
| NOAEL | =60 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Allyl Methacrylate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableAcute ToxicityEnvironmental Hazard
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 2; Acute Tox. 3; Acute Tox. 4; Aquatic Acute 1
Hazard Statements
- H226 Flammable liquid and vapour
- H330 Fatal if inhaled
- H311 Toxic in contact with skin
- H302 Harmful if swallowed
- H400 Very toxic to aquatic life
Specific Concentration Limits / M-factors
inhalation: ATE = 1.5 mg/L vapours; dermal: ATE = 300.0 mg/kg bw; oral: ATE = 400.0 mg/kg bw
Inserted via ATP: ATP21
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Methacrylates ... produce slight to moderate skin and eye irritation ... depending upon volatility, these materials also may be sensory irritants. /Methacrylic acid & derivatives/ | A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Allyl Methacrylate.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Allyl Methacrylate by CAS number or substance name.
Studies
2
Lowest NOAEL
25 mg/kg bw/day
Highest NOAEL
60 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Propenoic acid, 2-methyl-, 2-propenyl ester
2-Propenoic acid, 2-methyl-, 2-propen-1-yl ester
Ageflex AMA
BRN 1747406
EINECS 202-473-0
Methacrylic acid, allyl ester
NSC 18597
Allylester kyseliny methakrylove
UNII-G2IG50653Z
Chemical Function
No specific technical function
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1889548
Frequently Asked Questions
Is Allyl Methacrylate allowed in the EU?
Allyl Methacrylate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Allyl Methacrylate do in cosmetics?
Allyl Methacrylate functions as: Cross-linking monomer; used as a building block for polymers in cosmetics (film forming, viscosity controlling). It is classified as a cosmetic ingredient in our database. CAS number: 96-05-9.
What is the NOAEL for Allyl Methacrylate?
The NOAEL (No Observed Adverse Effect Level) for Allyl Methacrylate is =25 mg/kg bw/day based on a acute study via dermal route in Rabbit. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Allyl Methacrylate used outside cosmetics?
Allyl Methacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Allyl Methacrylate have different safety status in cosmetics vs industrial chemicals?
Allyl Methacrylate is classified GHS Danger (H226, H302, H311, H312, H330, H331, H373, H400) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Allyl Methacrylate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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