Is Acetonylacetone (2,5-Hexanedione) safe in cosmetics?
Acetonylacetone (2,5-Hexanedione) has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
Acetonylacetone (2,5-Hexanedione)
Also known as: 4-01-00-03688, Acetone, acetonyl-, BRN 0506525, EINECS 203-738-3, 2,5-Hexandione (+4 more)
INCI: ACETONYLACETONE
Acetonylacetone (2,5-Hexanedione) (CAS 110-13-4) is a cosmetic cosmetic ingredient functioning as Solvent. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 110-13-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Acetonylacetone (2,5-Hexanedione) is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H373).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not specifically restricted in cosmetics; however, recognized as a neurotoxic compound by OSHA/NIOSH
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetonylacetone (2,5-Hexanedione).
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Acetonylacetone (2,5-Hexanedione).
Regulatory Flags
prop65
Known Synonyms
4-01-00-03688
Acetone, acetonyl-
BRN 0506525
EINECS 203-738-3
2,5-Hexandione
UNII-C0Z8884J3P
2,5-Hexadione
CH3COCH2CH2COCH3
alpha,beta-Diacetylethane
Chemical Function
Fragrance
Regulatory Lists
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1564795
Frequently Asked Questions
Is Acetonylacetone (2,5-Hexanedione) allowed in the EU?
Acetonylacetone (2,5-Hexanedione) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetonylacetone (2,5-Hexanedione) do in cosmetics?
Acetonylacetone (2,5-Hexanedione) functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 110-13-4.
Is Acetonylacetone (2,5-Hexanedione) used outside cosmetics?
Acetonylacetone (2,5-Hexanedione) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acetonylacetone (2,5-Hexanedione) have different safety status in cosmetics vs industrial chemicals?
Acetonylacetone (2,5-Hexanedione) is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H373).
Compliance Tools
Check Acetonylacetone (2,5-Hexanedione) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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