What is the NOAEL for 2,5-Hexanedione?
2,5-Hexanedione has 16 NOAEL studies in the database. The lowest reported value is male listing type. Source: California Proposition 65.
NOAEL Data
Prop 65
REACH Registered
Cosmetic Ingredient
2,5-Hexanedione
Also known as: Acetonylacetone, 4-01-00-03688, Acetone, acetonyl-, BRN 0506525, EINECS 203-738-3 (+5 more)
CAS 110-13-4
2,5-Hexanedione (CAS 110-13-4) is a chemical substance; key hazard signal: male. Key regulatory status: California Proposition 65, REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, CA Prop 65.
View cosmetic safety profile for Acetonylacetone (2,5-Hexanedione) →
Cross-Vertical Regulatory Divergence
2,5-Hexanedione is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H373).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
2,5-Hexanedione
CAS Number
110-13-4
DTXSID
DTXSID8030138
Molecular Formula
C6H10O2
InChI Key
OJVAMHKKJGICOG-UHFFFAOYSA-N
Monoisotopic Mass
114.06808
Synonyms
Acetonylacetone4-01-00-03688Acetone, acetonyl-BRN 0506525EINECS 203-738-32,5-HexandioneUNII-C0Z8884J3P2,5-HexadioneCH3COCH2CH2COCH3alpha,beta-Diacetylethane
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | male | No | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| SQEmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| C0Z8884J3P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C0Z8884J3P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C0Z8884J3P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C0Z8884J3P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.93 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =2076 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~0.64 | mg/kg bw/day | LEL | oral | Monkey | ToxValDB_ECHA_IUCLID |
| ~100 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| ~200 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| ~370 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~400 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| ~2000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexane-2,5-dione | 203-738-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1564795
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 2,5-Hexanedione?
2,5-Hexanedione appears on 2 regulatory/inventory lists including OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023). Source: EPA CPDat.
Is 2,5-Hexanedione on the California Proposition 65 list?
Yes, 2,5-Hexanedione is listed under California Proposition 65 for male. Source: California OEHHA Proposition 65.
Is 2,5-Hexanedione used in cosmetics?
Yes, 2,5-Hexanedione is also indexed as a cosmetic ingredient under the name Acetonylacetone (2,5-Hexanedione). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,5-Hexanedione come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,5-Hexanedione have different safety status in cosmetics vs industrial chemicals?
2,5-Hexanedione is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H373).
Is 2,5-Hexanedione used outside industrial chemicals?
2,5-Hexanedione also appears in cosmetics, pharmaceutical databases.