NOAEL Studies Cosmetic Ingredient

Acetaldehyde Diethyl Acetal NOAEL Studies

INCI: ACETALDEHYDE DIETHYL ACETAL

CAS: 105-57-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =120 mg/kg bw/day Rat oral: drinking water 77 days subchronic EFSA FEEDAP - 2013 - OutputID 2209 - other - hepatotoxicity - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =4600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_481; row=10512; data_type=In Vivo; mixture=Chemical; chemical_name=Acetal; preferred_name=Acetal; dtxsid=DTXSID6030607; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6030607; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6030607; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2763; Record_ID=skin_sensitization_invivo_735; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6030607; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90175-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6030607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6030607
NTP_ICE_skin_sensitization Induction dose per skin area 6480 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2762; Record_ID=skin_sensitization_invivo_735; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6030607; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90175-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6030607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6030607
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2765; Record_ID=skin_sensitization_invivo_735; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6030607; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90175-3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6030607; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6030607
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5G14F9E2HB UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5G14F9E2HB"}
openFDA substances FDA UNII substance identifier 5G14F9E2HB UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5G14F9E2HB"}
openFDA substances FDA UNII substance identifier 5G14F9E2HB UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5G14F9E2HB"}
openFDA substances FDA UNII substance identifier 5G14F9E2HB UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5G14F9E2HB"}