Danger GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Acetal

Also known as: Acetaldehyde, diethyl acetal, NSC 7624, UN 1088 (DOT), EC No.: 203-310-6, Acetaldehyde diethyl acetal (+12 more)

CAS 105-57-7

Acetal (CAS 105-57-7) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H315; H319. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Acetaldehyde Diethyl Acetal →

Cross-Vertical Regulatory Divergence

Acetal is classified GHS Danger (H225, H315, H319) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

Acetal

CAS Number

105-57-7

DTXSID

DTXSID6030607

Molecular Formula

C6H14O2

InChI Key

DHKHKXVYLBGOIT-UHFFFAOYSA-N

Monoisotopic Mass

118.09938

Synonyms

Acetaldehyde, diethyl acetalNSC 7624UN 1088 (DOT)EC No.: 203-310-6Acetaldehyde diethyl acetalBRN 1098310EINECS 203-310-6Ethylidenediethyl etherFEMA No. 20021,1-Diaethoxy-aethan1,1-Diethoxy-ethaan1,1-Dietossietano

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 2; Skin Irrit. 2; Eye Irrit. 2	H225; H315; H319	GHS02; GHS07	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. Exposure could cause lowering of consciousness.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records

List	Keyword	Source
air; detected; emissions; Personal care	Elsevier	CPCat
detected; Europe; Personal care - body adhesive	Danish Environmental Protection Agency	Danish EPA
Europe	European Commission	Fl@vis
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 9 of 9 studies

Value	Unit	Endpoint	Route	Species	Source
5G14F9E2HB	UNII	FDA UNII substance identifier	-	-	openFDA substances
5G14F9E2HB	UNII	FDA UNII substance identifier	-	-	openFDA substances
5G14F9E2HB	UNII	FDA UNII substance identifier	-	-	openFDA substances
5G14F9E2HB	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
6480	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=4600	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=120	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 9 of 9 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	1,1-diethoxyethane	203-310-6	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1338583

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Acetal?

Acetal (CAS 105-57-7) is classified under EU CLP Annex VI as Flam. Liq. 2; Skin Irrit. 2; Eye Irrit. 2 with signal word Danger. Hazard statements: H225; H315; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Acetal?

Acetal has 9 NOAEL studies in the database. The lowest reported value is 5G14F9E2HB UNII. Source: openFDA substances.

What regulatory lists include Acetal?

Acetal appears on 8 regulatory/inventory lists including air; detected; emissions; Personal care, detected; Europe; Personal care - body adhesive, Europe, and 5 more. Source: EPA CPDat.

Is Acetal used in cosmetics?

Yes, Acetal is also indexed as a cosmetic ingredient under the name Acetaldehyde Diethyl Acetal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Acetal come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Acetal have different safety status in cosmetics vs industrial chemicals?

Acetal is classified GHS Danger (H225, H315, H319) in the chemicals database but is allowed in EU cosmetics.

Is Acetal used outside industrial chemicals?

Acetal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.