Also known as: Phenol, 4,4'-(1-methylethylidene)bis-, polymer with, Epidian, UP 5-207, Araldit LY 556, Bisphenol A epichlorohydrin polymer
INCI: BISPHENOL A/EPICHLOROHYDRIN COPOLYMER
4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer (CAS 25068-38-6) is a cosmetic cosmetic ingredient functioning as Film former used in nail lacquers and coatings. Reported NOAEL =60 mg/kg bw/day in Rabbit (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
US NotesPermitted; used in nail products. FDA has not banned the copolymer.
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer.
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Toxicological Studies
2 study endpoints found for 4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=60 mg/kg bw/day
oral
Rabbit
reproduction developmental
ToxValDB_ECHA_IUCLID
NOAEL
=180 mg/kg bw/day
oral
Rat
reproduction developmental
ToxValDB_ECHA_IUCLID
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Is 4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer safe in cosmetics?
4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Is 4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer allowed in the EU?
4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer do in cosmetics?
4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer functions as: Film former used in nail lacquers and coatings. It is classified as a cosmetic ingredient in our database. CAS number: 25068-38-6.
What is the NOAEL for 4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer?
The NOAEL (No Observed Adverse Effect Level) for 4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer is =60 mg/kg bw/day based on a reproduction developmental study via oral route in Rabbit. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is 4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer used outside cosmetics?
4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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