Also known as: 1,2-Cyclopentanedione, 3,5-dimethyl-, CYCLOPENTA-1,2-DIONE, 3,5-DIMETHYL-, 3,5-Dimethylcyclopentane-1,2-dione, EC No.: 236-811-3, EINECS 236-811-3 (+2 more)
INCI: 3,4-DIMETHYLCYCLOPENTANE-1,2-DIONE
3,4-Dimethylcyclopentane-1,2-Dione (CAS 13494-07-0) is a cosmetic cosmetic ingredient functioning as Perfuming / flavoring (alpha-diketone, butterscotch-type note). NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
US NotesNot restricted in cosmetics; FEMA GRAS as a flavoring
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3,4-Dimethylcyclopentane-1,2-Dione.
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Toxicological Studies
1 study endpoint found for 3,4-Dimethylcyclopentane-1,2-Dione. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
500 mg/kg bw/day
oral
rat
Subchronic
COSMOS DB
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 3,4-Dimethylcyclopentane-1,2-Dione across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
421
Source: WHO/JECFA
JECFA Evaluation
3,5-DIMETHYL-1,2-CYCLO-PENTANEDIONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/103 | FAS 42-JECFA 51/353
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrientFragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency ListFDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 3,4-Dimethylcyclopentane-1,2-Dione.
Is 3,4-Dimethylcyclopentane-1,2-Dione safe in cosmetics?
3,4-Dimethylcyclopentane-1,2-Dione has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Is 3,4-Dimethylcyclopentane-1,2-Dione allowed in the EU?
3,4-Dimethylcyclopentane-1,2-Dione EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3,4-Dimethylcyclopentane-1,2-Dione do in cosmetics?
3,4-Dimethylcyclopentane-1,2-Dione functions as: Perfuming / flavoring (alpha-diketone, butterscotch-type note). It is classified as a cosmetic ingredient in our database. CAS number: 13494-07-0.
What is the NOAEL for 3,4-Dimethylcyclopentane-1,2-Dione?
The NOAEL (No Observed Adverse Effect Level) for 3,4-Dimethylcyclopentane-1,2-Dione is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS DB.
Is 3,4-Dimethylcyclopentane-1,2-Dione used outside cosmetics?
3,4-Dimethylcyclopentane-1,2-Dione also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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