NOAEL Studies Cosmetic Ingredient

3,4-Dimethylcyclopentane-1,2-Dione NOAEL Studies

INCI: 3,4-DIMETHYLCYCLOPENTANE-1,2-DIONE

CAS: 13494-07-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =200 mg/kg bw/day Rat - - chronic/long term toxicity EFSA FEEDAP - 2016 - OutputID 2887 - body weight - systemic - Safety and efficacy of secondary aliphatic saturated or unsaturated alcohols, ketones, ketals and esters with a second secondary or tertiary oxygenated functional group belonging to chemical group 10 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4618
EFSA NOAEL =200 mg/kg bw/day Rat oral - chronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of secondary aliphatic saturated or unsaturated alcohols, ketones, ketals and esters with a second secondary or tertiary oxygenated functional group belonging to chemical group 10 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4618.; TITLE=Safety and efficacy of secondary aliphatic saturated or unsaturated alcohols, ketones, ketals and esters with a second secondary or tertiary oxygenated functional group belonging to chemical group 10 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4618; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15622146:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f08a9ea56f60c46ee120a5850bc76376
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier DV18V4XD6W UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DV18V4XD6W"}
openFDA substances FDA UNII substance identifier DV18V4XD6W UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DV18V4XD6W"}
openFDA substances FDA UNII substance identifier DV18V4XD6W UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DV18V4XD6W"}
openFDA substances FDA UNII substance identifier DV18V4XD6W UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DV18V4XD6W"}