What is the NOAEL for 2-Methylbutanoic acid?
2-Methylbutanoic acid has 34 NOAEL studies in the database. The lowest reported value is 1 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Methylbutanoic acid
Also known as: 2-Methylbutyric acid, 4-02-00-00889, BRN 1098537, EINECS 204-145-2, EINECS 209-982-7 (+15 more)
CAS 116-53-0
2-Methylbutanoic acid (CAS 116-53-0) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Methylbutanoic acid is classified GHS Danger (H302, H312, H314, H318, H290) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
34
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
2-Methylbutanoic acid
CAS Number
116-53-0
DTXSID
DTXSID5021621
Molecular Formula
C5H10O2
InChI Key
WLAMNBDJUVNPJU-UHFFFAOYSA-N
Monoisotopic Mass
102.06808
Synonyms
2-Methylbutyric acid4-02-00-00889BRN 1098537EINECS 204-145-2EINECS 209-982-7FEMA No. 2695Valeric acid, activeUNII-PX7ZNN5GXK(+/-)-2-Methylbutyrate(+/-)-2-Methylbutyric acid2-Ethylpropionate2-Ethylpropionic acid
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
FragranceFlavouring and nutrientDispersing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 34 of 34 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| PX7ZNN5GXK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PX7ZNN5GXK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PX7ZNN5GXK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| PX7ZNN5GXK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 0.02 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =125 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >219 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >219 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >300 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =340 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =340 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1450 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1450 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >2500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 0.7 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 3.2 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 3.6 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 5.6 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 35.9 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 80.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 83 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.2 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 3.9 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 5 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 34 of 34 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methylbutyric acid | 204-145-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1160012
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methylbutanoic acid?
2-Methylbutanoic acid appears on 5 regulatory/inventory lists including Canada; pharmaceutical, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is 2-Methylbutanoic acid used in cosmetics?
Yes, 2-Methylbutanoic acid is also indexed as a cosmetic ingredient under the name 2-Methylbutyric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methylbutanoic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Methylbutanoic acid have different safety status in cosmetics vs industrial chemicals?
2-Methylbutanoic acid is classified GHS Danger (H302, H312, H314, H318, H290) in the chemicals database but is allowed in EU cosmetics.
Is 2-Methylbutanoic acid used outside industrial chemicals?
2-Methylbutanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.