What is the NOAEL for 2'-Acetonaphthone?
2'-Acetonaphthone has 18 NOAEL studies in the database. The lowest reported value is 1.63 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2'-Acetonaphthone
Also known as: 4-07-00-01294, 2-Acetonaphthone, beta-Acetylnaphthalene, BRN 0774965, Cetone D (+10 more)
CAS 93-08-3
2'-Acetonaphthone (CAS 93-08-3) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
2'-Acetonaphthone
CAS Number
93-08-3
DTXSID
DTXSID2041389
Molecular Formula
C12H10O
InChI Key
XSAYZAUNJMRRIR-UHFFFAOYSA-N
Monoisotopic Mass
170.073165
Synonyms
4-07-00-012942-Acetonaphthonebeta-AcetylnaphthaleneBRN 0774965Cetone DEINECS 202-216-2FEMA No. 2723Ketone, methyl 2-naphthylbeta-Naphthyl methyl ketoneOranger crystalsOranger cyrstalsUNII-21D49LOP2T
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
34 records
DeodorizerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 32.598468960281 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 50.5714407806539 | uM | ACC | - | - | NTP_ICE_endocrine |
| =1.63 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 21D49LOP2T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 21D49LOP2T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 21D49LOP2T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 21D49LOP2T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00257 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =33 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =33 | mg/kg | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =33 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =33 | mg/kg | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =33 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 36.9 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2'-acetonaphthone | 202-216-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183700
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2'-Acetonaphthone?
2'-Acetonaphthone appears on 5 regulatory/inventory lists including SCIL (9/2019), Europe, IFRA Transparency, and 2 more. Source: EPA CPDat.
Is 2'-Acetonaphthone used in cosmetics?
Yes, 2'-Acetonaphthone is also indexed as a cosmetic ingredient under the name 2-Acetonaphthone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2'-Acetonaphthone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2'-Acetonaphthone used outside industrial chemicals?
2'-Acetonaphthone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.