NOAEL Studies Cosmetic Ingredient

2-Acetonaphthone NOAEL Studies

INCI: 2-ACETONAPHTHONE

CAS: 93-08-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 36.9 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =33 mg/kg Rat oral: feed 90 days subchronic EFSA AFC - 2006 - OutputID 2231 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 16: Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2006.330
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =33 mg/kg bw/day Rat - 90 days subchronic EFSA AFC - 2008 - OutputID 2287 - Flavouring Group Evaluation 69, (FGE.69): Consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting) structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16 (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.869
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =33 mg/kg Rat oral: feed 90 days subchronic EFSA AFC - 2006 - OutputID 2231 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 16: Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2006.330
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =33 mg/kg bw/day Rat - 90 days subchronic EFSA AFC - 2008 - OutputID 2287 - Flavouring Group Evaluation 69, (FGE.69): Consideration of aromatic substituted secondary alcohols, ketones and related esters evaluated by JECFA (57th meeting) structurally related to aromatic ketones from chemical group 21 evaluated by EFSA in FGE.16 (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.869
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 32.598468960281 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2140; RecordID=ERPathway2016_471; DatasetName=ERPathway2016; DTXSID=DTXSID2041389; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=32.598468960281; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389
NTP_ICE_endocrine ACC 50.5714407806539 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2141; RecordID=ERPathway2016_471; DatasetName=ERPathway2016; DTXSID=DTXSID2041389; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=50.5714407806539; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2136; RecordID=ARPathway2016_1725; DatasetName=ARPathway2016; DTXSID=DTXSID2041389; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389
NTP_ICE_endocrine Model Score 0.00257 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=2142; RecordID=ERPathway2016_471; DatasetName=ERPathway2016; DTXSID=DTXSID2041389; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00257; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11086; Record_ID=skin_sensitization_invivo_2424; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2041389; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90256-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389
NTP_ICE_skin_sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11084; Record_ID=skin_sensitization_invivo_2424; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2041389; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90256-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11089; Record_ID=skin_sensitization_invivo_2424; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2041389; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90256-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2041389
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =33 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA AFC (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 16: Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000). doi:10.2903/j.efsa.2006.330.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 16: Aromatic ketones from chemical group 21 (Commission Regulation (EC) No 1565/2000 of 18 July 2000); AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2006.330; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA_dup_-_15620821_15620822_15620823:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5abf1f2077c2fcc2c73f3a7c328bc721
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.63 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629473:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f5273b47f4b055410691a5406d1c8c56
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 21D49LOP2T UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"21D49LOP2T"}
openFDA substances FDA UNII substance identifier 21D49LOP2T UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"21D49LOP2T"}
openFDA substances FDA UNII substance identifier 21D49LOP2T UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"21D49LOP2T"}
openFDA substances FDA UNII substance identifier 21D49LOP2T UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"21D49LOP2T"}