NOAEL Data REACH Registered Cosmetic Ingredient

Safranal

Also known as: Dehydro-beta-cyclocitral, EINECS 204-133-7, FEMA No. 3389, 2,6,6-Trimethyl-1,3-cyclohexadienal, (2,6,6-Trimethylcyclohexa-1,3-dienyl)methanal (+4 more)

CAS 116-26-7

Safranal (CAS 116-26-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 2,3-Dihydro-2,2,6-trimethylbenzaldehyde (Safranal) →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields

Name

Safranal

CAS Number

116-26-7

DTXSID

DTXSID7049398

Molecular Formula

C10H14O

InChI Key

SGAWOGXMMPSZPB-UHFFFAOYSA-N

Monoisotopic Mass

150.104465

Synonyms

Dehydro-beta-cyclocitralEINECS 204-133-7FEMA No. 33892,6,6-Trimethyl-1,3-cyclohexadienal(2,6,6-Trimethylcyclohexa-1,3-dienyl)methanalUNII-4393FR07EA1,1,3-Trimethyl-2-formylcyclohexa-2,4-diene2,6,6-Trimethylcyclohexa-1,3-dienyl methanal2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
Europe	European Commission	Fl@vis
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
12.4	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
0.27	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.1	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
=3.08	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
91.8	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
-	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
5.39	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
7.5	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
4393FR07EA	UNII	FDA UNII substance identifier	-	-	openFDA substances
4393FR07EA	UNII	FDA UNII substance identifier	-	-	openFDA substances
4393FR07EA	UNII	FDA UNII substance identifier	-	-	openFDA substances
4393FR07EA	UNII	FDA UNII substance identifier	-	-	openFDA substances
337.3	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
339.1	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
9.434	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
300	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
160	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
60	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
=120	mg/kg bw/day	LEL	oral	Rat	ToxValDB_EFSA
=125	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=10	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_EFSA
=10	mg/kg bw/day	NOEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=10	mg/kg bw/day	NOEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=50	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
4	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2,3-dihydro-2,2,6-trimethylbenzaldehyde	204-133-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3183495

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Safranal?

Safranal has 26 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Safranal?

Safranal appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is Safranal used in cosmetics?

Yes, Safranal is also indexed as a cosmetic ingredient under the name 2,3-Dihydro-2,2,6-trimethylbenzaldehyde (Safranal). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Safranal come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Safranal used outside industrial chemicals?

Safranal also appears in cosmetics, pharmaceutical, cannabis databases.