Is 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL safe in cosmetics?
1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL
Also known as: EINECS 278-022-7, UNII-Q80X769AD4
1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL (CAS 74918-21-1) is a cosmetic cosmetic ingredient functioning as Not Reported. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 74918-21-1 →
Auto-generated CPSR Part A draft with source citations
Function
Not Reported
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-[3-(2,4-diaminophenoxy)propoxy]benzene-1,3-diamine;tetrahydrochloride
InChIKey
UXPUOLAAWYPPLE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
100%
DPRA Lys %
23.2%
KeratinoSens IC50
500 µM
hCLAT CV75
493.7 µg/mL
LLNA EC3
14.7%
NESIL
3675 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
EINECS 278-022-7
UNII-Q80X769AD4
Chemical Function
Dye
No specific technical function
Regulatory Lists
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL allowed in the EU?
1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL do in cosmetics?
1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 74918-21-1.
Is 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL used outside cosmetics?
1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Arginine
Excellent
Same category
Amino acid / pH Adjuster
D-Panthenol
Excellent
Same category
Hair and skin conditioning, humectant...
Dicaprylyl Ether
Excellent
Same category
Emollient
Emulsifying Wax
Excellent
Same category
O/W emulsifier; stabilizes oil-in-wat...
Ethyl Butyrate
Excellent
Same category
Perfuming, Masking
Fructose
Excellent
Same category
Humectant, Skin Conditioning, Flavori...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
(ARCTIUM LAPPA/CARROT/COLOCASIA ESCULENTA/DIOSCOREA BATATAS/GARLIC/GINGER/IPOMOEA BATATAS/NELUMBO NUCIFERA/ONION/POTATO BULBS)/(CHESTNUT/CITRUS UNSHIU/EGGPLANT/FIG/GRAPE/KIWI/LYCOPERSICON ESCULENTUM/MALUS PUMILA/MUME/PEACH/PLUM/PUMPKIN/PYRUS SEROTINA/RADISH/ZIZIPHUS JUJUBA FRUIT)/(ALLIUM TUBEROSUM/ALOE BARBADENSIS/ANGELICA UTILIS/BRASSICA OLERACEA ACEPHALA/CABBAGE/CELERY/SACCHARINA JAPONICA/UNDARIA PINNATIFIDA LEAF)/(ALLIUM FISTULOSUM/ENTEROMORPHA COMPRESSA/OENANTHE JAVANICA STALK)/LENTINULA EDODES/SUCROSE FERMENT FILTRATE
Good
Similar safety
Humectant, Skin Conditioning - Humect...
1,3,4,6-Tetramethyl-2-Pyrimidone Sulfate
Moderate
Browse nearby
Hair dyeing
1,3-Bis-(2,4-Diaminophenoxy)Propane
Moderate
Browse nearby
Oxidative and non-oxidative hair dye ...
1,3-Bis-(Isocyanatomethyl) Cyclohexane
Poor
Browse nearby
Monomer / cross-linking agent used in...
Is 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL in your formulation.