What is the NOAEL for 1,3-Bis(isocyanatomethyl)cyclohexane?
1,3-Bis(isocyanatomethyl)cyclohexane has 5 NOAEL studies in the database. The lowest reported value is EYM450423G UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,3-Bis(isocyanatomethyl)cyclohexane
Also known as: 1,3-Bis(methylisocyanate)cyclohexane, Cyclohexane, 1,3-bis(isocyanatomethyl)-, 1,3-Bis(methylisocyanate)cyclohexane [Diisocyanates]
CAS 38661-72-2
1,3-Bis(isocyanatomethyl)cyclohexane (CAS 38661-72-2) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, EPA TRI.
View cosmetic safety profile for 1,3-Bis-(Isocyanatomethyl) Cyclohexane →
Cross-Vertical Regulatory Divergence
1,3-Bis(isocyanatomethyl)cyclohexane is classified GHS Danger (H302, H312, H314, H315, H317, H318, H319, H330) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
9 fields
Name
1,3-Bis(isocyanatomethyl)cyclohexane
CAS Number
38661-72-2
DTXSID
DTXSID6044933
Molecular Formula
C10H14N2O2
InChI Key
XSCLFFBWRKTMTE-UHFFFAOYSA-N
Monoisotopic Mass
194.105528
Synonyms
1,3-Bis(methylisocyanate)cyclohexaneCyclohexane, 1,3-bis(isocyanatomethyl)-1,3-Bis(methylisocyanate)cyclohexane [Diisocyanates]
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
No specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| EYM450423G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EYM450423G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EYM450423G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EYM450423G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =570 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,3-bis(isocyanatomethyl)cyclohexane | 609-567-4 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
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EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| 1,3-Bis(isocyanatomethyl)cyclohexane | N120 - Diisocyanates | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
What regulatory lists include 1,3-Bis(isocyanatomethyl)cyclohexane?
1,3-Bis(isocyanatomethyl)cyclohexane appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 1,3-Bis(isocyanatomethyl)cyclohexane used in cosmetics?
Yes, 1,3-Bis(isocyanatomethyl)cyclohexane is also indexed as a cosmetic ingredient under the name 1,3-Bis-(Isocyanatomethyl) Cyclohexane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,3-Bis(isocyanatomethyl)cyclohexane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, EPA Toxics Release Inventory, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 1,3-Bis(isocyanatomethyl)cyclohexane have different safety status in cosmetics vs industrial chemicals?
1,3-Bis(isocyanatomethyl)cyclohexane is classified GHS Danger (H302, H312, H314, H315, H317, H318, H319, H330) in the chemicals database but is allowed in EU cosmetics.
Is 1,3-Bis(isocyanatomethyl)cyclohexane used outside industrial chemicals?
1,3-Bis(isocyanatomethyl)cyclohexane also appears in cosmetics databases.