Chemical Family
Sorted by lowest NOAEL first
Preservatives NOAEL Comparison
This page compares public raw NOAEL endpoint rows for Phenoxyethanol, Methylisothiazolinone, Benzisothiazolinone, Chlorphenesin, Sodium Benzoate. Values are pulled from noael_studies_public with NOAEL endpoint, mg/kg-family unit, and non-threshold qualifier filters.
Substances
5
With NOAEL Rows
4
Unique Sources
7
Lowest Indexed NOAEL
0.018 mg/kg bw/d
Benzisothiazolinone
Compare Families
Source Agreement Highlights
Benzisothiazolinone
Wide disagreement
Highest indexed NOAEL is 228,611.1111x the lowest.
SCCS_vision_codex, ToxValDB_ECHA_IUCLID, SCCNFP_vision_codex
Sodium Benzoate
Wide disagreement
Highest indexed NOAEL is 1,201.3889x the lowest.
INCHEM_WHO_jecfa_jecmono_v1037je01, INCHEM_WHO_jecfa_jecmono_v83je01, COSMOS_DB, ToxValDB_ECHA_IUCLID
Methylisothiazolinone
Wide disagreement
Highest indexed NOAEL is 4.98x the lowest.
CIR_vision_codex, SCCNFP_vision_codex, ToxValDB_ECHA_IUCLID
| Substance | CAS | Lowest NOAEL | Highest NOAEL | # Studies | EU Status | Sources |
|---|---|---|---|---|---|---|
| Benzisothiazolinone | 2634-33-5 | 0.018 mg/kg bw/d | 4,115 mg/kg bw | 29 | restricted; max Permitted in rinse-off cosmetics; restricted or banned in leave-on products | SCCS_vision_codex, ToxValDB_ECHA_IUCLID, SCCNFP_vision_codex
Wide disagreement |
| Phenoxyethanol | 122-99-6 | 2 mg/kg | 1,000 mg/kg bw/day | 44 | restricted; max 1.0% | SCCS_vision_codex
Single source |
| Sodium Benzoate | 532-32-1 | 3.6 mg/kg bw/day | 4,325 mg/kg bw/day | 32 | restricted; max 0.5% as benzoic acid equivalent | INCHEM_WHO_jecfa_jecmono_v1037je01, INCHEM_WHO_jecfa_jecmono_v83je01, COSMOS_DB +1 more
Wide disagreement |
| Methylisothiazolinone | 2682-20-4 | 10 mg/kg/d | 49.8 mg/kg bw/d | 34 | restricted; max 0.0015% in rinse-off cosmetics only; banned in all leave-on cosmetics | CIR_vision_codex, SCCNFP_vision_codex, ToxValDB_ECHA_IUCLID
Wide disagreement |
| Chlorphenesin | 104-29-0 | - | - | 0 | restricted; max 0.3% | -
No NOAEL rows |