Chemical Family
Sorted by lowest NOAEL first
Fragrance Allergens NOAEL Comparison
This page compares public raw NOAEL endpoint rows for Linalool, Limonene, Citronellol, Geraniol, Citral, Coumarin. Values are pulled from noael_studies_public with NOAEL endpoint, mg/kg-family unit, and non-threshold qualifier filters.
Substances
6
With NOAEL Rows
4
Unique Sources
4
Lowest Indexed NOAEL
6 mg/kg bw
Citral
Compare Families
Source Agreement Highlights
| Substance | CAS | Lowest NOAEL | Highest NOAEL | # Studies | EU Status | Sources |
|---|---|---|---|---|---|---|
| Citral | 5392-40-5 | 6 mg/kg bw | 820 mg/kg bw/day | 8 | restricted; max 10 ppm in leave-on products, 100 ppm in rinse-off products | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx, COSMOS_DB
Wide disagreement |
| Geraniol | 106-24-1 | 50 mg/kg bw/day | 500 mg/kg bw/day | 3 | restricted; max 10 ppm in leave-on products, 100 ppm in rinse-off products | COSMOS_DB, ToxValDB_ECHA_IUCLID
Wide disagreement |
| Limonene | 5989-27-5 | 60 mg/kg bw/day | 825 mg/kg bw/day | 5 | restricted; max >0.001% leave-on, >0.01% rinse-off (mandatory label declaration) | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx, ToxValDB_ECHA_IUCLID
Wide disagreement |
| Linalool | 78-70-6 | 1,000 mg/kg bw/day | 1,000 mg/kg bw/day | 1 | restricted; max Mandatory individual label declaration above 10 ppm in leave-on products, 100 ppm in rinse-off products (EU 26 allergen list). IFRA 51st Amendment imposes stricter limits on linalool hydroperoxide content in formulations. | COSMOS_DB
Single source |
| Citronellol | 106-22-9 | - | - | 0 | restricted; max Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off under Regulation (EU) 2023/1545; IFRA restrictions apply | -
No NOAEL rows |
| Coumarin | 91-64-5 | - | - | 0 | restricted; max 10 ppm in leave-on products, 100 ppm in rinse-off products | -
No NOAEL rows |