Chemical Family
Sorted by lowest NOAEL first
Parabens NOAEL Comparison
This page compares public raw NOAEL endpoint rows for Methylparaben, Ethylparaben, Propylparaben, Butylparaben, Isopropylparaben, Isobutylparaben. Values are pulled from noael_studies_public with NOAEL endpoint, mg/kg-family unit, and non-threshold qualifier filters.
Substances
6
With NOAEL Rows
4
Unique Sources
5
Lowest Indexed NOAEL
0.105 mg/kg bw/day
Methylparaben
Compare Families
Source Agreement Highlights
Methylparaben
Wide disagreement
Highest indexed NOAEL is 11,238.0952x the lowest.
SCCS_vision_codex, CIR_vision_codex, COSMOS_DB, ToxValDB_ECHA_IUCLID
Propylparaben
Wide disagreement
Highest indexed NOAEL is 2,850x the lowest.
SCCS_vision_codex, ToxValDB_ECHA_IUCLID, COSMOS_DB
| Substance | CAS | Lowest NOAEL | Highest NOAEL | # Studies | EU Status | Sources |
|---|---|---|---|---|---|---|
| Methylparaben | 99-76-3 | 0.105 mg/kg bw/day | 1,180 mg/kg bw/day | 58 | restricted; max 0.4% (as acid); mixture cap all parabens 0.8% | SCCS_vision_codex, CIR_vision_codex, COSMOS_DB +1 more
Wide disagreement |
| Propylparaben | 94-13-3 | 2 mg/kg/day | 5,700 mg/kg bw/day | 76 | restricted; max 0.14% (as acid) | SCCS_vision_codex, ToxValDB_ECHA_IUCLID, COSMOS_DB
Wide disagreement |
| Butylparaben | 94-26-8 | 2 mg/kg bw/day | 1,504 mg/kg bw/day | 120 | restricted; max 0.14% (as acid) | SCCS_vision_codex
Single source |
| Ethylparaben | 120-47-8 | 1,030 mg/kg bw/day | 1,030 mg/kg bw/day | 2 | restricted; max 0.4% single ester; 0.8% mixture of esters (sum of methyl+ethyl+propyl+butylparaben) | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Single source |
| Isopropylparaben | 4191-73-5 | - | - | 0 | prohibited | -
No NOAEL rows |
| Isobutylparaben | 4247-02-3 | - | - | 0 | prohibited | -
No NOAEL rows |