Is Vinylidene Difluoride safe in cosmetics?
Vinylidene Difluoride has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Vinylidene Difluoride
Also known as: Ethene, 1,1-difluoro-, EINECS 200-867-7, Halocarbon 1132A, NCI-C60204, NCI-C60208 (+5 more)
INCI: VINYLIDENE DIFLUORIDE (1,1-DIFLUOROETHYLENE)
Vinylidene Difluoride (CAS 75-38-7) is a cosmetic cosmetic ingredient functioning as Monomer/precursor for PVDF polymers; limited direct cosmetic use — primarily an. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 75-38-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Vinylidene Difluoride is classified GHS Danger (H220, H230, H280, H340, H350, H336) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Monomer/precursor for PVDF polymers; limited direct cosmetic use — primarily an industrial chemical
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1,1-difluoroethene
InChIKey
BQCIDUSAKPWEOX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not FDA-approved for direct cosmetic use; NIOSH REL: TWA 1 ppm
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Vinylidene Difluoride.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the central nervous system.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
39, Sup 7, 71
Evaluation Year
1998
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Vinylidene fluoride | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 39: (1986) Some Chemicals Used in Plastics and Elastomers | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
No epidemiological data relevant to the carcinogenicity of vinylidene fluoride were available. There is inadequate evidence for the carcinogenicity of vinylidene fluoride in experimental animals. Overall evaluation Vinylidene fluoride is not classifiable as to its carcinogenicity to humans (Group 3). | A4: Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0687
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritating to skin and pulmonary tract ...
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Vinylidene Difluoride.
Known Synonyms
Ethene, 1,1-difluoro-
EINECS 200-867-7
Halocarbon 1132A
NCI-C60204
NCI-C60208
UNII-3C1IX2905B
HFC-1132a
VF2
C2H2F2
CF2=CH2
Chemical Function
No specific technical function
Regulatory Lists
Indirect additives food contact (10/2018)
drinking_water; Europe; manufacturing; plastic_additive
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL116020
Frequently Asked Questions
Is Vinylidene Difluoride allowed in the EU?
Vinylidene Difluoride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Vinylidene Difluoride do in cosmetics?
Vinylidene Difluoride functions as: Monomer/precursor for PVDF polymers; limited direct cosmetic use — primarily an industrial chemical. It is classified as a cosmetic ingredient in our database. CAS number: 75-38-7.
Is Vinylidene Difluoride used outside cosmetics?
Vinylidene Difluoride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Vinylidene Difluoride have different safety status in cosmetics vs industrial chemicals?
Vinylidene Difluoride is classified GHS Danger (H220, H230, H280, H340, H350, H336) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Vinylidene Difluoride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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ACETALDEHYDE
Moderate
Chemical family
Fragrance
Chlorofluorocarbons (CFCs)
Poor
Chemical family
aerosol propellants
DICHLOROMETHANE
Moderate
Chemical family
Perfuming, Solvent
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