Is Tripeptide-32 safe in cosmetics?
Tripeptide-32 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Tripeptide-32
INCI: TRIPEPTIDE-32
Tripeptide-32 (CAS 1185583-20-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning (CLOCK/PER1 gene activation for circadian rhythm. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1185583-20-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (CLOCK/PER1 gene activation for circadian rhythm synchronization, DNA repair, oxidative stress defense)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S)-1-[(2S,3R)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carboxamide
InChIKey
FUYMMLFZSQBBKU-XGEHTFHBSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA classification or restriction. Not reviewed by CIR (CIR covers Tripeptide-1 but not Tripeptide-32). Falls under general cosmetic ingredient framework. MoCRA compliance required.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tripeptide-32.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Tripeptide-32.
Regulatory Flags
data-gap
proprietary-data
no-cir-review
no-sccs-opinion
no-peer-reviewed-safety-data
read-across-required
Frequently Asked Questions
Is Tripeptide-32 allowed in the EU?
Tripeptide-32 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tripeptide-32 do in cosmetics?
Tripeptide-32 functions as: Skin conditioning (CLOCK/PER1 gene activation for circadian rhythm synchronization, DNA repair, oxidative stress defense). It is classified as a cosmetic ingredient in our database. CAS number: 1185583-20-3.
Compliance Tools
Check Tripeptide-32 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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