Trimethylolpropane Trimethacrylate (CAS 3290-92-4) is a cosmetic cosmetic ingredient functioning as Film forming, binding agent (primarily nail/UV-cure systems). Reported NOAEL =300 mg/kg bw/day in Rabbit (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
US NotesCIR reviewed alongside acrylate family; permitted with concentration limits
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylolpropane Trimethacrylate.
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Toxicological Studies
1 study endpoint found for Trimethylolpropane Trimethacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=300 mg/kg bw/day
oral
Rabbit
developmental
ToxValDB_ECHA_IUCLID
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Is Trimethylolpropane Trimethacrylate safe in cosmetics?
Trimethylolpropane Trimethacrylate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Is Trimethylolpropane Trimethacrylate allowed in the EU?
Trimethylolpropane Trimethacrylate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylolpropane Trimethacrylate do in cosmetics?
Trimethylolpropane Trimethacrylate functions as: Film forming, binding agent (primarily nail/UV-cure systems). It is classified as a cosmetic ingredient in our database. CAS number: 3290-92-4.
What is the NOAEL for Trimethylolpropane Trimethacrylate?
The NOAEL (No Observed Adverse Effect Level) for Trimethylolpropane Trimethacrylate is =300 mg/kg bw/day based on a developmental study via oral route in Rabbit. Source: ToxValDB_ECHA_IUCLID.
Is Trimethylolpropane Trimethacrylate used outside cosmetics?
Trimethylolpropane Trimethacrylate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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