Moderate Cosmetic Ingredient NOAEL Data

Trimethylolpropane Trimethacrylate

INCI: TRIMETHYLOLPROPANE TRIMETHACRYLATE

Trimethylolpropane Trimethacrylate (CAS 3290-92-4) is a cosmetic cosmetic ingredient functioning as Film forming, binding agent (primarily nail/UV-cure systems). Reported NOAEL =300 mg/kg bw/day in Rabbit (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.

View industrial chemical safety profile for CAS 3290-92-4 →

Auto-generated CPSR Part A draft with source citations
Function
Film forming, binding agent (primarily nail/UV-cure systems)
Safety Rating
MODERATE

Chemistry & Identifiers

Formula
C18H26O6
MW
338.4 g/mol
EC Number
221-950-4
PubChem CID
18689
IUPAC Name
2,2-bis(2-methylprop-2-enoyloxymethyl)butyl 2-methylprop-2-enoate
InChIKey
OKKRPWIIYQTPQF-UHFFFAOYSA-N

Regulatory Status

EU EU Status prohibited
US US Status permitted
US Notes CIR reviewed alongside acrylate family; permitted with concentration limits

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylolpropane Trimethacrylate.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Trimethylolpropane Trimethacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =300 mg/kg bw/day oral Rabbit developmental ToxValDB_ECHA_IUCLID

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter Catalyst Chemical reaction regulator Film former Hardener

Expert Verdict

Expert safety assessment and concern-level summary for Trimethylolpropane Trimethacrylate.

Regulatory Flags

potential-allergen

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Trimethylolpropane Trimethacrylate by CAS number or substance name.

Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Chemical Function

Film former Chemical reaction regulator Catalyst

Regulatory Lists

drinking_water; Europe; manufacturing; plastic_additive

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID
CHEMBL1901244
View full pharmaceutical profile →

Frequently Asked Questions

Is Trimethylolpropane Trimethacrylate safe in cosmetics?

Trimethylolpropane Trimethacrylate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Trimethylolpropane Trimethacrylate allowed in the EU?

Trimethylolpropane Trimethacrylate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Trimethylolpropane Trimethacrylate do in cosmetics?

Trimethylolpropane Trimethacrylate functions as: Film forming, binding agent (primarily nail/UV-cure systems). It is classified as a cosmetic ingredient in our database. CAS number: 3290-92-4.

What is the NOAEL for Trimethylolpropane Trimethacrylate?

The NOAEL (No Observed Adverse Effect Level) for Trimethylolpropane Trimethacrylate is =300 mg/kg bw/day based on a developmental study via oral route in Rabbit. Source: ToxValDB_ECHA_IUCLID.

Is Trimethylolpropane Trimethacrylate used outside cosmetics?

Trimethylolpropane Trimethacrylate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Is Trimethylolpropane Trimethacrylate in Your Products?

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