NOAEL Studies Cosmetic Ingredient

Trimethylolpropane Trimethacrylate NOAEL Studies

INCI: TRIMETHYLOLPROPANE TRIMETHACRYLATE

CAS: 3290-92-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_5574; row=5902; data_type=In Vivo; mixture=Chemical; chemical_name=Trimethylolpropane trimethacrylate; preferred_name=1,1,1-Trimethylolpropane trimethacrylate; dtxsid=DTXSID3027530; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3027530; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL <2500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6ba; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13937/7/9/3?documentUUID=0caf3a0f-f1d7-4471-aced-9338bb74860a; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=ECHA IUCLID:15824756:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a78c064eecb3f4dd0c7c546c85a0ab40
ToxValDB_ECHA_IUCLID LOAEL =1000 mg/kg bw/day Rat oral chronic; 93 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c7872; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13937/7/6/2?documentUUID=0caf3a0f-f1d7-4471-aced-9338bb74860a; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|body weight and weight gain|food consumption and compound intake|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|neurobehavior|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847324_15848222:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_562f10d707e413b265d91125a29b6b53
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1cfe4b0a7c65d230490; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13937/7/9/3?documentUUID=0caf3a0f-f1d7-4471-aced-9338bb74860a; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=fetus: external malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820884_15823774:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76bf250e316d99ecb4d053e4d6866db6
ToxValDB_ECHA_IUCLID NOAEL >1000 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13937/7/9/3?documentUUID=0caf3a0f-f1d7-4471-aced-9338bb74860a; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=ECHA IUCLID:15823394:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b7872201e0638b948f08c8ba32d95eb1
ToxValDB_ECHA_IUCLID NOAEL >900 mg/kg bw/day Rat oral subchronic; 5 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c786e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13937/7/6/2?documentUUID=0caf3a0f-f1d7-4471-aced-9338bb74860a; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=ECHA IUCLID:15849396:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d36ca4a3fe02cebc933a650928d5aa9
ToxValDB_ECHA_IUCLID NOEL =1000 mg/kg bw/day Rabbit oral short-term; 7 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb14e4b0a7c65d224c32; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13937/7/6/2?documentUUID=0caf3a0f-f1d7-4471-aced-9338bb74860a; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=ECHA IUCLID:15840532:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e757ef53c3939b262757f60cdc7c417
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =29.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634402:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f07e58c716eccb522431fb5c869cfca2
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier S734UC120F UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S734UC120F"}
openFDA substances FDA UNII substance identifier S734UC120F UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S734UC120F"}
openFDA substances FDA UNII substance identifier S734UC120F UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S734UC120F"}
openFDA substances FDA UNII substance identifier S734UC120F UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S734UC120F"}