What is the NOAEL for 1,1,1-Trimethylolpropane trimethacrylate?
1,1,1-Trimethylolpropane trimethacrylate has 12 NOAEL studies in the database. The lowest reported value is 29.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,1,1-Trimethylolpropane trimethacrylate
Also known as: 2-Propenoic acid, 2-methyl-, 2-ethyl-2-[[(2-methyl-1-oxo-2-propenyl)oxy]methyl]-1,3-propanediyl ester, 2-Propenoic acid, 2-methyl-, 1,1′-[2-ethyl-2-[[(2-methyl-1-oxo-2-propen-1-yl)oxy]methyl]-1,3-propanediyl] ester, BRN 5961805, EINECS 221-950-4, 2-Ethyl-2(hydroxymethyl)-1,3-propanediol trimethacrylate (+15 more)
CAS 3290-92-4
1,1,1-Trimethylolpropane trimethacrylate (CAS 3290-92-4) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Trimethylolpropane Trimethacrylate →
Cross-Vertical Regulatory Divergence
1,1,1-Trimethylolpropane trimethacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
1,1,1-Trimethylolpropane trimethacrylate
CAS Number
3290-92-4
DTXSID
DTXSID3027530
Molecular Formula
C18H26O6
InChI Key
OKKRPWIIYQTPQF-UHFFFAOYSA-N
Monoisotopic Mass
338.172939
Synonyms
2-Propenoic acid, 2-methyl-, 2-ethyl-2-[[(2-methyl-1-oxo-2-propenyl)oxy]methyl]-1,3-propanediyl ester2-Propenoic acid, 2-methyl-, 1,1′-[2-ethyl-2-[[(2-methyl-1-oxo-2-propen-1-yl)oxy]methyl]-1,3-propanediyl] esterBRN 5961805EINECS 221-950-42-Ethyl-2(hydroxymethyl)-1,3-propanediol trimethacrylateMethacrylic acid, 1,1,1-trihydroxymethyl propane triesterNK Ester M TMPT1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-, trimethacrylatePTMA (VAN)Trimethylolpropane trimethancrylateUNII-S734UC120FTMPT
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
18 records
Film formerChemical reaction regulatorCatalystAdhesion/cohesion promoterHardener
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =29.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| S734UC120F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S734UC120F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S734UC120F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S734UC120F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <2500 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| >900 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >1000 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propylidynetrimethyl trimethacrylate | 221-950-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1901244
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 1,1,1-Trimethylolpropane trimethacrylate?
1,1,1-Trimethylolpropane trimethacrylate appears on 1 regulatory/inventory list including drinking_water; Europe; manufacturing; plastic_additive. Source: EPA CPDat.
Is 1,1,1-Trimethylolpropane trimethacrylate used in cosmetics?
Yes, 1,1,1-Trimethylolpropane trimethacrylate is also indexed as a cosmetic ingredient under the name Trimethylolpropane Trimethacrylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,1,1-Trimethylolpropane trimethacrylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 1,1,1-Trimethylolpropane trimethacrylate have different safety status in cosmetics vs industrial chemicals?
1,1,1-Trimethylolpropane trimethacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H411).
Is 1,1,1-Trimethylolpropane trimethacrylate used outside industrial chemicals?
1,1,1-Trimethylolpropane trimethacrylate also appears in cosmetics, pharmaceutical databases.