Is TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL safe in cosmetics?
TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL
Also known as: Polysantol, 4-Penten-2-ol, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-, 3,3-Dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol
TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL (CAS 107898-54-4) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 300 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 107898-54-4 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(E)-3,3-dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol
InChIKey
QZFSNJAQFWEXEA-MDZDMXLPSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / IrritantEnvironmental Hazard
Hazard Class and Category
Skin Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H315 Causes skin irritation
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
5000 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [210] RIFM (2001): RIFM report number 41998, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 104 | 0 | 2598 | 2598 | non-sensitizer |
| HRIPT | - | 0 | 5000 | - | - |
| HRIPT | - | 0 | 10000 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Polysantol
4-Penten-2-ol, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
3,3-Dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL allowed in the EU?
TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL do in cosmetics?
TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 107898-54-4.
What is the NOAEL for TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL?
The NOAEL (No Observed Adverse Effect Level) for TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL is =300 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL used outside cosmetics?
TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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