NOAEL Studies
Cosmetic Ingredient
TRIMETHYLCYCLOPENTENYL DIMETHYLISOPENTENOL NOAEL Studies
CAS: 107898-54-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE skin irritation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Viability | 7.8 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4922; Record_ID=skin_irritation_invitro_344; Data_Type=In Vitro; Formulation_Name=(+/–) trans-3,3-dimethyl-5-(2,2,3-trimethyl-cyclopent-3-en-1-yl)-pent-4-en-2-ol; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=EpiDerm Irritation; Endpoint=Viability; Response=7.8; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin irritation | Viability | 8.83 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4923; Record_ID=skin_irritation_invitro_345; Data_Type=In Vitro; Formulation_Name=(+/–) trans-3,3-dimethyl-5-(2,2,3-trimethyl-cyclopent-3-en-1-yl)-pent-4-en-2-ol; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=EpiSkin Irritation; Endpoint=Viability; Response=8.83; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin irritation | Viability | 9.79 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4924; Record_ID=skin_irritation_invitro_346; Data_Type=In Vitro; Formulation_Name=(+/–) trans-3,3-dimethyl-5-(2,2,3-trimethyl-cyclopent-3-en-1-yl)-pent-4-en-2-ol; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=EpiSkin Irritation; Endpoint=Viability; Response=9.79; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin irritation | Viability | 11.02 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4925; Record_ID=skin_irritation_invitro_347; Data_Type=In Vitro; Formulation_Name=(+/–) trans-3,3-dimethyl-5-(2,2,3-trimethyl-cyclopent-3-en-1-yl)-pent-4-en-2-ol; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=EpiDerm Irritation; Endpoint=Viability; Response=11.02; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin irritation | Viability | 11.71 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4926; Record_ID=skin_irritation_invitro_348; Data_Type=In Vitro; Formulation_Name=(+/–) trans-3,3-dimethyl-5-(2,2,3-trimethyl-cyclopent-3-en-1-yl)-pent-4-en-2-ol; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=EpiSkin Irritation; Endpoint=Viability; Response=11.71; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin irritation | Viability | 14.07 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4927; Record_ID=skin_irritation_invitro_349; Data_Type=In Vitro; Formulation_Name=(+/–) trans-3,3-dimethyl-5-(2,2,3-trimethyl-cyclopent-3-en-1-yl)-pent-4-en-2-ol; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=EpiDerm Irritation; Endpoint=Viability; Response=14.07; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
NTP ICE skin sensitization 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 54.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3311; Record_ID=skin_sensitization_invivo_840; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=54.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31374298; 10.1016/j.fct.2019.110715; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin sensitization | Concentration, one positive response | 10 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3306; Record_ID=skin_sensitization_invivo_840; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=10; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31374298; 10.1016/j.fct.2019.110715; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3319; Record_ID=skin_sensitization_invivo_842; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2005; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2019; 31374298; 10.1016/j.fct.2019.110715; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin sensitization | Incidence of positive responses | 0.9174 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3302; Record_ID=skin_sensitization_invivo_840; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0.9174; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31374298; 10.1016/j.fct.2019.110715; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin sensitization | Induction dose per skin area | 10000 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3317; Record_ID=skin_sensitization_invivo_842; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=10000; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2005; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2019; 31374298; 10.1016/j.fct.2019.110715; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 27250 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3313; Record_ID=skin_sensitization_invivo_840; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=27250; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31374298; 10.1016/j.fct.2019.110715; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 5000 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3309; Record_ID=skin_sensitization_invivo_840; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=5000; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31374298; 10.1016/j.fct.2019.110715; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3315; Record_ID=skin_sensitization_invivo_840; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7051551; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 2001; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31374298; 10.1016/j.fct.2019.110715; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7051551 |
ECHA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =300 | mg/kg bw/day | Rat | oral | - | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0de4b0a7c65d21ff58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/13419?documentUUID=5c59ced9-4706-4169-a4a0-78e702b6897e; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15833999:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_27377291d2ab2a25f87e7612efc4b2fc |