Is Triethylhexyl Trimellitate safe in cosmetics?
Triethylhexyl Trimellitate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Triethylhexyl Trimellitate
Also known as: Tris (2-ethylhexyl) trimellitate, 1,2,4-Benzenetricarboxylic acid, 1,2,4-tris(2-ethylhexyl) ester, 1,2,4-Benzenetricarboxylic acid, tris(2-ethylhexyl) ester, ADK Cizer TOTM, Adekacizer TOTM (+15 more)
INCI: TRIETHYLHEXYL TRIMELLITATE (SYNONYM: TOTM — TRIS(2-ETHYLHEXYL) TRIMELLITATE)
Triethylhexyl Trimellitate (CAS 3319-31-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (emollient), plasticizer (high-performance,. Reported NOAEL =1050 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3319-31-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent (emollient), plasticizer (high-performance, low-volatility ester)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
InChIKey
KRADHMIOFJQKEZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; FDA also allows in food-contact materials (indirect additive)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Triethylhexyl Trimellitate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Triethylhexyl Trimellitate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1050 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Suspected
Evidence: Limited
(2012)
Health effects: No
Affected pathways: Anti-androgenic
Regulatory framework: REACH
Source list: II
Dose-Response Data Points
| Endpoint | Target | Value | Direction |
|---|---|---|---|
| Estradiol secretion | steroidogenesis | EC50/IC50: LOEC E2: 0.3 uM; max 2-fold uparrow E2 at 10 uM; LOEC: 0.3 uM; NOEC: 0.1 uM mixed | modulator (uparrow E2) |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Plasticizer
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Triethylhexyl Trimellitate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Triethylhexyl Trimellitate by CAS number or substance name.
Studies
1
Lowest NOAEL
1050 mg/kg bw/day
Highest NOAEL
1050 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Tris (2-ethylhexyl) trimellitate
1,2,4-Benzenetricarboxylic acid, 1,2,4-tris(2-ethylhexyl) ester
1,2,4-Benzenetricarboxylic acid, tris(2-ethylhexyl) ester
ADK Cizer TOTM
Adekacizer TOTM
Bisoflex TOT
Codan Set 43.4400
Diplast TM/ST
Hatcol 200
Monocizer W 700
Monocizer W 705
Monocizer W 710L
Nuoplaz 6959
Octyl trimellitate
Pelemol TOTM
Plasthall TOTM
Reomol OTM
Sansocizer TOTM
TOTM
TOTM-I
Chemical Function
Softener and conditioner
Plasticizer
Regulatory Lists
Europe; plastic_additive
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1425782
Frequently Asked Questions
Is Triethylhexyl Trimellitate allowed in the EU?
Triethylhexyl Trimellitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triethylhexyl Trimellitate do in cosmetics?
Triethylhexyl Trimellitate functions as: Skin conditioning agent (emollient), plasticizer (high-performance, low-volatility ester). It is classified as a cosmetic ingredient in our database. CAS number: 3319-31-1.
What is the NOAEL for Triethylhexyl Trimellitate?
The NOAEL (No Observed Adverse Effect Level) for Triethylhexyl Trimellitate is =1050 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Triethylhexyl Trimellitate used outside cosmetics?
Triethylhexyl Trimellitate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Triethylhexyl Trimellitate compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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