What is the NOAEL for Tris(2-ethylhexyl) trimellitate?
Tris(2-ethylhexyl) trimellitate has 21 NOAEL studies in the database. The lowest reported value is 3.97 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tris(2-ethylhexyl) trimellitate
Also known as: Tris (2-ethylhexyl) trimellitate, 1,2,4-Benzenetricarboxylic acid, 1,2,4-tris(2-ethylhexyl) ester, 1,2,4-Benzenetricarboxylic acid, tris(2-ethylhexyl) ester, ADK Cizer TOTM, Adekacizer TOTM (+15 more)
CAS 3319-31-1
Tris(2-ethylhexyl) trimellitate (CAS 3319-31-1) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Triethylhexyl Trimellitate →
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Tris(2-ethylhexyl) trimellitate
CAS Number
3319-31-1
DTXSID
DTXSID9026265
Molecular Formula
C33H54O6
InChI Key
KRADHMIOFJQKEZ-UHFFFAOYSA-N
Monoisotopic Mass
546.392039
Synonyms
Tris (2-ethylhexyl) trimellitate1,2,4-Benzenetricarboxylic acid, 1,2,4-tris(2-ethylhexyl) ester1,2,4-Benzenetricarboxylic acid, tris(2-ethylhexyl) esterADK Cizer TOTMAdekacizer TOTMBisoflex TOTCodan Set 43.4400Diplast TM/STHatcol 200Monocizer W 700Monocizer W 705Monocizer W 710L
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
27 records
Softener and conditionerPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 44.5503606199792 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 22.8394933776476 | uM | ACC | - | - | NTP_ICE_endocrine |
| =3.97 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 378539Q830 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 378539Q830 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 378539Q830 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 378539Q830 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >3200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =650 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.115 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =184 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =225 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =225 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =225 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =1050 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate | 222-020-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1425782
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Tris(2-ethylhexyl) trimellitate?
Tris(2-ethylhexyl) trimellitate appears on 1 regulatory/inventory list including Europe; plastic_additive. Source: EPA CPDat.
Is Tris(2-ethylhexyl) trimellitate used in cosmetics?
Yes, Tris(2-ethylhexyl) trimellitate is also indexed as a cosmetic ingredient under the name Triethylhexyl Trimellitate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tris(2-ethylhexyl) trimellitate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Tris(2-ethylhexyl) trimellitate used outside industrial chemicals?
Tris(2-ethylhexyl) trimellitate also appears in cosmetics, pharmaceutical, cannabis databases.