NOAEL Studies
Cosmetic Ingredient
Triethylhexyl Trimellitate NOAEL Studies
INCI: TRIETHYLHEXYL TRIMELLITATE (SYNONYM: TOTM — TRIS(2-ETHYLHEXYL) TRIMELLITATE)
CAS: 3319-31-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =225 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA CEP - 2019 - OutputID 3325 - organ weights - hepatotoxicity - Safety assessment of the substance trimellitic acid, tris (2-ethylhexyl) ester, for use in food contact materials - doi:10.2903/j.efsa.2019.5864 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =225 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA CEP - 2019 - OutputID 3325 - organ weights - hepatotoxicity - Safety assessment of the substance trimellitic acid, tris (2-ethylhexyl) ester, for use in food contact materials - doi:10.2903/j.efsa.2019.5864 |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >3200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_5634; row=15675; data_type=In Vivo; mixture=Chemical; chemical_name=Tris(2-ethylhexyl) trimellitate; preferred_name=Tris(2-ethylhexyl) trimellitate; dtxsid=DTXSID9026265; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026265; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9026265; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_5632; row=15676; data_type=In Vivo; mixture=Chemical; chemical_name=Tris(2-ethylhexyl) trimellitate; preferred_name=Tris(2-ethylhexyl) trimellitate; dtxsid=DTXSID9026265; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026265; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9026265; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 44.5503606199792 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=16146; RecordID=ERPathway2016_228; DatasetName=ERPathway2016; DTXSID=DTXSID9026265; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=44.5503606199792; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026265; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026265 |
| NTP_ICE_endocrine | ACC | 22.8394933776476 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=16147; RecordID=ERPathway2016_228; DatasetName=ERPathway2016; DTXSID=DTXSID9026265; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=22.8394933776476; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026265; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026265 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=16142; RecordID=ARPathway2016_1146; DatasetName=ARPathway2016; DTXSID=DTXSID9026265; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026265; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026265 |
| NTP_ICE_endocrine | Model Score | 0.115 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16148; RecordID=ERPathway2016_228; DatasetName=ERPathway2016; DTXSID=DTXSID9026265; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.115; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026265; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026265 |
ToxValDB_ECHA_IUCLID 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =1000 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c78ea; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14933/7/6/2?documentUUID=e79459bd-8a3d-4193-abe8-b0ee3f9a470b; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835905_15842188_15849399_15849400:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c3aba9a984525b480b09645bef20ed1 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1050 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac1ae4b0a7c65d1bd6c0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14933/7/9/3?documentUUID=e79459bd-8a3d-4193-abe8-b0ee3f9a470b; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824757_15824758:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0441c98309a015ac1e370cb6e8d0d9f4 |
| ToxValDB_ECHA_IUCLID | NOAEL | =225 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c78ea; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14933/7/6/2?documentUUID=e79459bd-8a3d-4193-abe8-b0ee3f9a470b; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835905_15842188_15849399_15849400:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_487cd034c690c5db31bfb106dc8cdf98 |
| ToxValDB_ECHA_IUCLID | NOEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8154; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14933/7/9/2?documentUUID=e79459bd-8a3d-4193-abe8-b0ee3f9a470b; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15862796:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_acf8d756ec244653ccff8a500607713f |
| ToxValDB_ECHA_IUCLID | NOEL | =100 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8154; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14933/7/9/2?documentUUID=e79459bd-8a3d-4193-abe8-b0ee3f9a470b; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15862797:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9e8b30166cd52fbcd9b3f38494b39394 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =3.97 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635563:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f29b19ffb45a135974ddf40f7d021ae |
ToxValDB_HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | LOAEL | =650 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=Chemical Manufacturers Association, Project No. 3.0496. Report NO. 0496/1/85CMA Reference. TM-3.0-BT-BIB; TITLE=Project No. 3.0496. Report NO. 0496/1/85CMA Reference. TM-3.0-BT-BIB; AUTHOR=Chemical Manufacturers Association; QUALITY=1; EXTERNAL_SOURCE_ID=60699; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639643_15639944:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eefe3edee51d7cf6e6f54fed42c41a49 |
| ToxValDB_HPVIS | NOAEL | =184 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=Chemical Manufacturers Association, Project No. 3.0496. Report NO. 0496/1/85CMA Reference. TM-3.0-BT-BIB; TITLE=Project No. 3.0496. Report NO. 0496/1/85CMA Reference. TM-3.0-BT-BIB; AUTHOR=Chemical Manufacturers Association; QUALITY=1; EXTERNAL_SOURCE_ID=62793; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639643_15639944:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b427fbd77208cb2f72b8606a84b0440b |
| ToxValDB_HPVIS | NOAEL | >1000 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=Toxicity Testing Reports of Environmental Chemicals,vol.4(1996))Ministry of Health & Welfare, Japan; TITLE=Toxicity Testing Reports of Environmental Chemicals; AUTHOR=Ministry of Health & Welfare, Japan; QUALITY=1; EXTERNAL_SOURCE_ID=63068; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=HPVIS:15639974:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_39d5e58ea979ba720e4f538813a45d28 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 378539Q830 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C33H54O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"378539Q830"} |
| openFDA substances | FDA UNII substance identifier | 378539Q830 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C33H54O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"378539Q830"} |
| openFDA substances | FDA UNII substance identifier | 378539Q830 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C33H54O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"378539Q830"} |
| openFDA substances | FDA UNII substance identifier | 378539Q830 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C33H54O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"378539Q830"} |