Is Tricaprylin safe in cosmetics?
Tricaprylin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Tricaprylin
Also known as: Octanoic acid triglyceride, Octanoic acid, 1,2,3-propanetriyl ester, Glycerin tricaprylate, Trioctanoin, 4-02-00-00991 (+14 more)
INCI: TRICAPRYLIN (GLYCEROL TRIOCTANOATE)
Tricaprylin (CAS 538-23-8) is a cosmetic cosmetic ingredient functioning as Emollient, moisturizing, skin conditioning, skin protecting, smoothing, solvent. Reported NOAEL =1908 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 538-23-8 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, moisturizing, skin conditioning, skin protecting, smoothing, solvent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2,3-di(octanoyloxy)propyl octanoate
InChIKey
VLPFTAMPNXLGLX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR assessed safe; GRAS food substance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tricaprylin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Tricaprylin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1908 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =4770 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Humectant
Softener and conditioner
Solvent
Regulatory List Membership (4)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Tricaprylin.
Regulatory Flags
eu_children_restricted
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tricaprylin by CAS number or substance name.
Studies
2
Lowest NOAEL
1908 mg/kg bw/day
Highest NOAEL
4770 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Octanoic acid triglyceride
Octanoic acid, 1,2,3-propanetriyl ester
Glycerin tricaprylate
Trioctanoin
4-02-00-00991
BRN 1717202
EINECS 208-686-5
Maceight
Panacete 800
Trioctanoin oil
UNII-6P92858988
1,2,3-Propanetriol trioctanoate
1,2,3-trioctanoylglycerol
Caprylic acid, 1,2,3-propanetriyl ester
Caprylic triglyceride
Glycerol tricaprylate
Glycerol trioctanoin
TG(8:0/8:0/8:0)
Axona
Chemical Function
Deodorizer
Softener and conditioner
Fragrance
Solvent
Regulatory Lists
consumer_product
detected; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe
detected; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
IFRA Transparency
artificial_saliva; detected; emissions; Europe; Furniture and Furnishings
children; Europe; Personal care
children; Europe; Personal care - general moisturizing - hand/body lotion
Europe; Personal care
Europe; Personal care
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TRICAPRILIN
ChEMBL ID
CHEMBL1406148
Max Phase
3
Frequently Asked Questions
Is Tricaprylin allowed in the EU?
Tricaprylin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tricaprylin do in cosmetics?
Tricaprylin functions as: Emollient, moisturizing, skin conditioning, skin protecting, smoothing, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 538-23-8.
What is the NOAEL for Tricaprylin?
The NOAEL (No Observed Adverse Effect Level) for Tricaprylin is =1908 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Tricaprylin used outside cosmetics?
Tricaprylin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tricaprylin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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