Is Tetramethyl-1-oxaspiro[4.5]dec-6-ene safe in cosmetics?
Tetramethyl-1-oxaspiro[4.5]dec-6-ene has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Tetramethyl-1-oxaspiro[4.5]dec-6-ene
Also known as: (+/-)-Theaspirane, Theaspirane, 1-Oxaspiro[4.5]dec-6-ene, 2,6,10,10-tetramethyl-, EINECS 253-031-9, FEMA No. 3774 (+9 more)
INCI: TETRAMETHYL-1-OXASPIRO-6-DECENE
Tetramethyl-1-oxaspiro[4.5]dec-6-ene (CAS 36431-72-8) is a cosmetic cosmetic ingredient functioning as Fragrance (Parfum) – theaspirane-type, black tea aroma. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 36431-72-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (Parfum) – theaspirane-type, black tea aroma
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,6,6,10-tetramethyl-1-oxaspiro[4.5]dec-9-ene
InChIKey
GYUZHTWCNKINPY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use as fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetramethyl-1-oxaspiro[4.5]dec-6-ene.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1238
Source: WHO/JECFA
JECFA Evaluation
THEASPIRANE | 2016 | No safety concern at current levels of intake when used as a flavouring agent | ">TRS 1000-JECFA 82/126 | FAS 52-JECFA 61/335
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Tetramethyl-1-oxaspiro[4.5]dec-6-ene.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
(+/-)-Theaspirane
Theaspirane
1-Oxaspiro[4.5]dec-6-ene, 2,6,10,10-tetramethyl-
EINECS 253-031-9
FEMA No. 3774
1-Oxaspiro-2,6,10,10-tetramethyl(4.5)dec-6-ene
UNII-7371A7GT6E
2,6,10,10-Tetramethyl-1-oxa-spiro[4.5]dec-6-ene
2,6,10,10-tetramethyl-oxa-spiro-dec-6-ene
6,9-Epoxy-4-megastigmene
Cis-theaspirane
2,6,10,10-tetramethyl-1-oxaspiro[4.5]dec-6-ene
EC No.: 253-031-9
253-031-9
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
THEASPIRANE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Tetramethyl-1-oxaspiro[4.5]dec-6-ene allowed in the EU?
Tetramethyl-1-oxaspiro[4.5]dec-6-ene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetramethyl-1-oxaspiro[4.5]dec-6-ene do in cosmetics?
Tetramethyl-1-oxaspiro[4.5]dec-6-ene functions as: Fragrance (Parfum) – theaspirane-type, black tea aroma. It is classified as a cosmetic ingredient in our database. CAS number: 36431-72-8.
Is Tetramethyl-1-oxaspiro[4.5]dec-6-ene used outside cosmetics?
Tetramethyl-1-oxaspiro[4.5]dec-6-ene also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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