What is the NOAEL for 2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene?
2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene has 4 NOAEL studies in the database. The lowest reported value is 7371A7GT6E UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene
Also known as: (+/-)-Theaspirane, Theaspirane, 1-Oxaspiro[4.5]dec-6-ene, 2,6,10,10-tetramethyl-, EINECS 253-031-9, FEMA No. 3774 (+8 more)
CAS 36431-72-8
2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene (CAS 36431-72-8) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Tetramethyl-1-oxaspiro[4.5]dec-6-ene →
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene
CAS Number
36431-72-8
DTXSID
DTXSID3047055
Molecular Formula
C13H22O
InChI Key
GYUZHTWCNKINPY-UHFFFAOYSA-N
Monoisotopic Mass
194.167065
Synonyms
(+/-)-TheaspiraneTheaspirane1-Oxaspiro[4.5]dec-6-ene, 2,6,10,10-tetramethyl-EINECS 253-031-9FEMA No. 37741-Oxaspiro-2,6,10,10-tetramethyl(4.5)dec-6-eneUNII-7371A7GT6E2,6,10,10-Tetramethyl-1-oxa-spiro[4.5]dec-6-ene2,6,10,10-tetramethyl-oxa-spiro-dec-6-ene6,9-Epoxy-4-megastigmeneCis-theaspiraneEC No.: 253-031-9
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7371A7GT6E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7371A7GT6E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7371A7GT6E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7371A7GT6E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene?
2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene used in cosmetics?
Yes, 2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene is also indexed as a cosmetic ingredient under the name Tetramethyl-1-oxaspiro[4.5]dec-6-ene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene used outside industrial chemicals?
2,6,10,10-Tetramethyl-1-oxaspiro[4.5]dec-6-ene also appears in cosmetics, food safety, cannabis databases.