Is Tetramethrin safe in cosmetics?
Tetramethrin has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Tetramethrin
Also known as: d-Tetramethrin, Bioneopynamin, Caswell No. 844, N-(Chrysanthemoxymethyl)-1-cyclohexene-1,2-dicarboximide, (1-Cyclohexane-1,2-dicarboximido)methyl chrysanthemumate (+15 more)
INCI: TETRAMETHRIN
Tetramethrin (CAS 7696-12-0) is a cosmetic cosmetic ingredient functioning as Insecticide/pesticide (pyrethroid) — not a typical cosmetic active. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7696-12-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetramethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H351, H371, H400, H410, H320).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Insecticide/pesticide (pyrethroid) — not a typical cosmetic active
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
(1,3-dioxo-4,5,6,7-tetrahydroisoindol-2-yl)methyl 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate
InChIKey
CXBMCYHAMVGWJQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not approved for cosmetic use; regulated by EPA as a pesticide
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetramethrin.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Health HazardHarmful / IrritantEnvironmental Hazard
Hazard Class and Category
Carc. 2; Acute Tox. 4; STOT SE 2; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H351 Suspected of causing cancer
- H302 Harmful if swallowed
- H371 (inhalation) (nervous system)
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
M = 100; M = 100
Inserted via ATP: ATP13
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1618
(EU) 2019/1966
CMR: Carcinogenic Cat. 2()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1618
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (5)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Evidence for Carcinogenicity
Cancer Classification: Group C Possible Human Carcinogen
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0334
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The chief effect from exposure ... is skin rash particularly on moist areas of the skin. ... May irritate the eyes. /Pyrethroids/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Tetramethrin.
Regulatory Flags
endocrine_disruptor
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
d-Tetramethrin
Bioneopynamin
Caswell No. 844
N-(Chrysanthemoxymethyl)-1-cyclohexene-1,2-dicarboximide
(1-Cyclohexane-1,2-dicarboximido)methyl chrysanthemumate
Cyclohex-1-ene-1,2-dicarboximidomethyl (+-)-cis-trans-chrysanthemate
Cyclohex-1-ene-1,2-dicarboximidomethyl (1RS)-cis,trans-2,2-dimethyl-3-(2-methyl-prop-1-enyl)cyclopropane carboxylate
1-(Cyclohexene-1,2-dicarboximido)methyl 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylate
1-Cyclohexene-1,2-dicarboximidomethyl-2,2-dimethyl-3-(2-methylpropenyl)cyclopropane carboxylate
2,2-Dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylic acid ester withN-(hydroxymethyl)-1-cyclohexene-1,2-dicarboximide
EINECS 231-711-6
EPA Pesticide Chemical Code 069003
(1,3,4,5,6,7-Hexahydro-1,3-dioxo-2H-isoindol-2-yl) methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate
Multicide
Neopynamin forte
Niagara nia-9260
d-Phthalthrin
Py-kill
SP 1103 forte
Sumitomo SP-1103
Chemical Function
Biocide
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TETRAMETHRIN
ChEMBL ID
CHEMBL1788386
Max Phase
4
Frequently Asked Questions
Is Tetramethrin allowed in the EU?
Tetramethrin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetramethrin do in cosmetics?
Tetramethrin functions as: Insecticide/pesticide (pyrethroid) — not a typical cosmetic active. It is classified as a cosmetic ingredient in our database. CAS number: 7696-12-0.
Is Tetramethrin used outside cosmetics?
Tetramethrin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetramethrin have different safety status in cosmetics vs industrial chemicals?
Tetramethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H351, H371, H400, H410, H320).
Compliance Tools
Check Tetramethrin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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