Warning GHS08GHS07GHS09 NOAEL Data Cosmetic Ingredient

Tetramethrin

Also known as: d-Tetramethrin, Bioneopynamin, Caswell No. 844, N-(Chrysanthemoxymethyl)-1-cyclohexene-1,2-dicarboximide, (1-Cyclohexane-1,2-dicarboximido)methyl chrysanthemumate (+15 more)

CAS 7696-12-0

Tetramethrin (CAS 7696-12-0) is a chemical substance with GHS signal word Warning; key hazard signal: H351; H302; H371 (inhalation) (nervous system); H400; H410. Key regulatory status: 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ILO ICSC, EPA TRI.

View cosmetic safety profile for Tetramethrin →

Cross-Vertical Regulatory Divergence

Tetramethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H302, H371, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Tetramethrin

CAS Number

7696-12-0

DTXSID

DTXSID6032649

Molecular Formula

C19H25NO4

InChI Key

CXBMCYHAMVGWJQ-UHFFFAOYSA-N

Monoisotopic Mass

331.178358

Synonyms

d-TetramethrinBioneopynaminCaswell No. 844N-(Chrysanthemoxymethyl)-1-cyclohexene-1,2-dicarboximide(1-Cyclohexane-1,2-dicarboximido)methyl chrysanthemumateCyclohex-1-ene-1,2-dicarboximidomethyl (+-)-cis-trans-chrysanthemateCyclohex-1-ene-1,2-dicarboximidomethyl (1RS)-cis,trans-2,2-dimethyl-3-(2-methyl-prop-1-enyl)cyclopropane carboxylate1-(Cyclohexene-1,2-dicarboximido)methyl 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylate1-Cyclohexene-1,2-dicarboximidomethyl-2,2-dimethyl-3-(2-methylpropenyl)cyclopropane carboxylate2,2-Dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylic acid ester withN-(hydroxymethyl)-1-cyclohexene-1,2-dicarboximideEINECS 231-711-6EPA Pesticide Chemical Code 069003

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Carc. 2; Acute Tox. 4; STOT SE 2; Aquatic Acute 1; Aquatic Chronic 1	H351; H302; H371 (inhalation) (nervous system); H400; H410	GHS08; GHS07; GHS09	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 2 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and skin.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Biocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
pharmaceutical	US International Trade Commission	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
detected; general_crops; Pesticides; residue	FDA	United States Food and Drug Administration (FDA)
detected; general_crops; Pesticides; residue	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 69 studies

Value	Unit	Endpoint	Route	Species	Source
76.97674149	uM	AC50	-	-	NTP_ICE_endocrine
56.81361373	uM	ACC	-	-	NTP_ICE_endocrine
37.6	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
4	unitless	EPA Classification	Inhalation	-	NTP_ICE_acute_inhalation
Z72930Q46K	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z72930Q46K	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z72930Q46K	UNII	FDA UNII substance identifier	-	-	openFDA substances
Z72930Q46K	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	fraction	Fu	-	Human	NTP_ICE_adme_parameters
>2.5	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=4600	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>4640	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=4900	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>20000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=0.6	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=0.6	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=17.1	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=17.1	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
=71.4	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=71.4	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
=75	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=75	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=100	mg/kg bw/day	LEL	oral	Dog	ToxValDB_ToxRefDB
=100	mg/kg bw/day	LEL	oral	dog (beagle; beagle)	ToxRefDB_ToxRefDB_v3_pod.csv
=150	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=150	mg/kg bw/day	LEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
=300	mg/kg bw/day	LEL	oral	Dog	ToxValDB_ToxRefDB
=300	mg/kg bw/day	LEL	oral	dog (beagle; beagle)	ToxRefDB_ToxRefDB_v3_pod.csv
=1000	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=1000	mg/kg bw/day	LEL	oral	rat (sprague dawley; Crl:COBS VAF CD (SD)BR)	ToxRefDB_ToxRefDB_v3_pod.csv
1000	nM	LEL	-	-	NTP_ICE_endocrine
=3	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ToxRefDB
=3	mg/kg bw/day	LOAEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=0.3	mg/kg bw/day	LOEL	injection	Rat	ToxValDB_ECOTOX
=5	mg/kg bw/day	LOEL	injection	Rat	ToxValDB_ECOTOX
=72	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0475	unitless	Model Score	-	-	NTP_ICE_endocrine
>-	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=5.83	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=5.83	mg/kg bw/day	NEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
=15	mg/kg bw/day	NEL	oral	Mouse	ToxValDB_ToxRefDB
=15	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=21.4	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=21.4	mg/kg bw/day	NEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
=25	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=25	mg/kg bw/day	NEL	oral	rat (sprague dawley; Sprague Dawley)	ToxRefDB_ToxRefDB_v3_pod.csv
=30	mg/kg bw/day	NEL	oral	Dog	ToxValDB_ToxRefDB
=30	mg/kg bw/day	NEL	oral	dog (beagle; beagle)	ToxRefDB_ToxRefDB_v3_pod.csv

Showing 50 of 69 studies

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Tetramethrin	-	-

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL TETRAMETHRIN

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Tetramethrin?

Tetramethrin (CAS 7696-12-0) is classified under EU CLP Annex VI as Carc. 2; Acute Tox. 4; STOT SE 2; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H351; H302; H371 (inhalation) (nervous system); H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Tetramethrin?

Tetramethrin has 69 NOAEL studies in the database. The lowest reported value is 0 fraction in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Tetramethrin?

Tetramethrin appears on 8 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, active_ingredient; Australia, and 5 more. Source: EPA CPDat.

Is Tetramethrin used in cosmetics?

Yes, Tetramethrin is also indexed as a cosmetic ingredient under the name Tetramethrin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Tetramethrin come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Tetramethrin have different safety status in cosmetics vs industrial chemicals?

Tetramethrin is prohibited in EU cosmetics but has active industrial GHS classifications (H351, H302, H371, H400, H410).

Is Tetramethrin used outside industrial chemicals?

Tetramethrin also appears in cosmetics, pharmaceutical databases.