Is Tetrahydrofurfuryl Methacrylate safe in cosmetics?
Tetrahydrofurfuryl Methacrylate has a safety rating of "POOR" in our database. EU status: restricted. US status: restricted.
Poor
Cosmetic Ingredient
Tetrahydrofurfuryl Methacrylate
Also known as: EINECS 219-529-5, Methacrylic acid tetrahydrofurfuryl ester, Tetrahydrofurfurylmethacrylate, UNII-120GN9C472
INCI: TETRAHYDROFURFURYL METHACRYLATE
Tetrahydrofurfuryl Methacrylate (CAS 2455-24-5) is a cosmetic cosmetic ingredient functioning as Film Forming – produces continuous film on nails; primary monomer in UV/LED gel. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2455-24-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetrahydrofurfuryl Methacrylate is classified GHS Danger (H315, H317, H319, H335, H360, H412, H227, H336) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film Forming – produces continuous film on nails; primary monomer in UV/LED gel polishes (≥50% concentration)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
oxolan-2-ylmethyl 2-methylprop-2-enoate
InChIKey
LCXXNKZQVOXMEH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Not specifically restricted; CIR assessed as safe in nail enhancement products when skin contact is avoided
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydrofurfuryl Methacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tetrahydrofurfuryl Methacrylate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardHarmful / Irritant
Hazard Class and Category
Repr. 1B; Skin Sens. 1A
Hazard Statements
- H360Df
- H317 May cause an allergic skin reaction
Inserted via ATP: ATP23
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
Methacrylates ... produce slight to moderate skin and eye irritation ... depending upon volatility, these materials also may be sensory irritants. /Methacrylic acid & derivatives/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Expert Verdict
Expert safety assessment and concern-level summary for Tetrahydrofurfuryl Methacrylate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tetrahydrofurfuryl Methacrylate by CAS number or substance name.
Studies
6
Lowest NOAEL
120 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
EINECS 219-529-5
Methacrylic acid tetrahydrofurfuryl ester
Tetrahydrofurfurylmethacrylate
UNII-120GN9C472
Chemical Function
Film former
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561338
Frequently Asked Questions
Is Tetrahydrofurfuryl Methacrylate allowed in the EU?
Tetrahydrofurfuryl Methacrylate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydrofurfuryl Methacrylate do in cosmetics?
Tetrahydrofurfuryl Methacrylate functions as: Film Forming – produces continuous film on nails; primary monomer in UV/LED gel polishes (≥50% concentration). It is classified as a cosmetic ingredient in our database. CAS number: 2455-24-5.
Is Tetrahydrofurfuryl Methacrylate used outside cosmetics?
Tetrahydrofurfuryl Methacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetrahydrofurfuryl Methacrylate have different safety status in cosmetics vs industrial chemicals?
Tetrahydrofurfuryl Methacrylate is classified GHS Danger (H315, H317, H319, H335, H360, H412, H227, H336) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Tetrahydrofurfuryl Methacrylate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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