Also known as: UNII-973IBV8W7I, 1,7-Bis(4-hydroxyphenyl)-heptane-3,5-dione, 3,5-Heptanedione, 1,7-bis(4-hydroxyphenyl)-, Bisdemethoxytetrahydrocurcumin, Tetrahydrobisdemethoxycurcumin (+1 more)
INCI: TETRAHYDROBISDEMETHOXYDIFERULOYLMETHANE
Tetrahydrobisdemethoxydiferuloylmethane (CAS 113482-94-3) is a cosmetic cosmetic ingredient functioning as Antioxidant, Skin conditioning, Oral care. Reported NOAEL =200 mg/kg bw/day in Rat (EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
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Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydrobisdemethoxydiferuloylmethane.
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2 study endpoints found for Tetrahydrobisdemethoxydiferuloylmethane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral: gavage | Rat | reproduction toxicity | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| NOAEL | =400 mg/kg bw/day | oral: gavage | Rat | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Tetrahydrobisdemethoxydiferuloylmethane.
Public NOAEL study rows linked to Tetrahydrobisdemethoxydiferuloylmethane by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Tetrahydrobisdemethoxydiferuloylmethane has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Tetrahydrobisdemethoxydiferuloylmethane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Tetrahydrobisdemethoxydiferuloylmethane functions as: Antioxidant, Skin conditioning, Oral care. It is classified as a cosmetic ingredient in our database. CAS number: 113482-94-3.
The NOAEL (No Observed Adverse Effect Level) for Tetrahydrobisdemethoxydiferuloylmethane is =200 mg/kg bw/day based on a reproduction toxicity study via oral: gavage route in Rat. A total of 2 study endpoints are available. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.
Tetrahydrobisdemethoxydiferuloylmethane also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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