NOAEL Studies Cosmetic Ingredient

Tetrahydrobisdemethoxydiferuloylmethane NOAEL Studies

INCI: TETRAHYDROBISDEMETHOXYDIFERULOYLMETHANE

CAS: 113482-94-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =200 mg/kg bw/day Rat oral: gavage 43 days reproduction toxicity EFSA NDA - 2021 - OutputID 4057 - reproduction - reproductive - Safety of tetrahydrocurcuminoids from turmeric (Curcuma longa L.) as a novel food pursuant to Regulation (EU) 2015/2283 - doi:10.2903/j.efsa.2021.6936
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =400 mg/kg bw/day Rat oral: gavage 90 days subchronic EFSA NDA - 2021 - OutputID 4057 - no adverse effect observed at single/highest dose - Safety of tetrahydrocurcuminoids from turmeric (Curcuma longa L.) as a novel food pursuant to Regulation (EU) 2015/2283 - doi:10.2903/j.efsa.2021.6936
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 973IBV8W7I UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"973IBV8W7I"}
openFDA substances FDA UNII substance identifier 973IBV8W7I UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"973IBV8W7I"}
openFDA substances FDA UNII substance identifier 973IBV8W7I UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"973IBV8W7I"}
openFDA substances FDA UNII substance identifier 973IBV8W7I UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"973IBV8W7I"}