Is Tetrahydro-dimethylbenzofuran safe in cosmetics?
Tetrahydro-dimethylbenzofuran has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Tetrahydro-dimethylbenzofuran
Also known as: EINECS 207-795-5, FEMA No. 3235, p-Mentha-3,8-diene, 3,9-epoxy-, Menthofurane, NSC 315249 (+12 more)
INCI: TETRAHYDRO-DIMETHYLBENZOFURAN
Tetrahydro-dimethylbenzofuran (CAS 494-90-6) is a cosmetic cosmetic ingredient functioning as Fragrance – herbal, minty-camphoraceous; also used in flavoring. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 494-90-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetrahydro-dimethylbenzofuran is classified GHS Danger (H301, H351, H372, H302, H315, H319, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance – herbal, minty-camphoraceous; also used in flavoring
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,6-dimethyl-4,5,6,7-tetrahydro-1-benzofuran
InChIKey
YGWKXXYGDYYFJU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted under FDA 21 CFR 172; FEMA 3235 (GRAS); TSCA listed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydro-dimethylbenzofuran.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
758
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
MENTHOFURAN | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/56 | FAS 46-JECFA 55/221
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Tetrahydro-dimethylbenzofuran.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
EINECS 207-795-5
FEMA No. 3235
p-Mentha-3,8-diene, 3,9-epoxy-
Menthofurane
NSC 315249
(+)-3,9-epoxy-p-mentha-3,8-diene
(+)-menthofuran
(6R)-3,6-dimethyl-4,5,6,7-tetrahydro-1-benzofuran
(R)-(+)-Menthofuran
(R)-4,5,6,7-tetrahydro-3,6-dimethylbenzofuran
3,6-Dimethyl-4,5,6,7-tetrahydro-1-benzofuran
3,9-Epoxy-(+)-p-Mentha-3,8-diene
3,9-epoxy-p-mentha-3,8-diene
4,5,6,7-Tetrahydro-3,6-dimethyl-(R)-Benzofuran
4,5,6,7-Tetrahydro-3,6-dimethyl-benzofuran
4,5,6,7-tetrahydro-3,6-dimethylbenzofuran
4,5,6,7-tetrahydro-3,6-dimethylcoumarone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MENTHOFURAN
ChEMBL ID
CHEMBL1522900
Frequently Asked Questions
Is Tetrahydro-dimethylbenzofuran allowed in the EU?
Tetrahydro-dimethylbenzofuran EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydro-dimethylbenzofuran do in cosmetics?
Tetrahydro-dimethylbenzofuran functions as: Fragrance – herbal, minty-camphoraceous; also used in flavoring. It is classified as a cosmetic ingredient in our database. CAS number: 494-90-6.
Is Tetrahydro-dimethylbenzofuran used outside cosmetics?
Tetrahydro-dimethylbenzofuran also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetrahydro-dimethylbenzofuran have different safety status in cosmetics vs industrial chemicals?
Tetrahydro-dimethylbenzofuran is classified GHS Danger (H301, H351, H372, H302, H315, H319, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tetrahydro-dimethylbenzofuran compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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