What is the NOAEL for Menthofuran?
Menthofuran has 6 NOAEL studies in the database. The lowest reported value is LK024V9U3C UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Menthofuran
Also known as: EINECS 207-795-5, FEMA No. 3235, p-Mentha-3,8-diene, 3,9-epoxy-, Menthofurane, NSC 315249 (+12 more)
CAS 494-90-6
Menthofuran (CAS 494-90-6) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Tetrahydro-dimethylbenzofuran →
Cross-Vertical Regulatory Divergence
Menthofuran is classified GHS Danger (H301, H351, H372, H302, H315, H319, H411) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Menthofuran
CAS Number
494-90-6
DTXSID
DTXSID9025534
Molecular Formula
C10H14O
InChI Key
YGWKXXYGDYYFJU-UHFFFAOYSA-N
Monoisotopic Mass
150.104465
Synonyms
EINECS 207-795-5FEMA No. 3235p-Mentha-3,8-diene, 3,9-epoxy-MenthofuraneNSC 315249(+)-3,9-epoxy-p-mentha-3,8-diene(+)-menthofuran(6R)-3,6-dimethyl-4,5,6,7-tetrahydro-1-benzofuran(R)-(+)-Menthofuran(R)-4,5,6,7-tetrahydro-3,6-dimethylbenzofuran3,6-Dimethyl-4,5,6,7-tetrahydro-1-benzofuran3,9-Epoxy-(+)-p-Mentha-3,8-diene
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| LK024V9U3C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LK024V9U3C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LK024V9U3C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| LK024V9U3C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 6 of 6 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
MENTHOFURAN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Menthofuran?
Menthofuran appears on 3 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe. Source: EPA CPDat.
Is Menthofuran used in cosmetics?
Yes, Menthofuran is also indexed as a cosmetic ingredient under the name Tetrahydro-dimethylbenzofuran. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Menthofuran come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Menthofuran have different safety status in cosmetics vs industrial chemicals?
Menthofuran is classified GHS Danger (H301, H351, H372, H302, H315, H319, H411) in the chemicals database but is allowed in EU cosmetics.
Is Menthofuran used outside industrial chemicals?
Menthofuran also appears in cosmetics, pharmaceutical, cannabis databases.