Is Tafluprost safe in cosmetics?
Tafluprost has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Tafluprost
INCI: ETHYL TAFLUPROSTAMIDE (COSMETIC INCI); INN: TAFLUPROST
Tafluprost (CAS 209860-87-7) is a cosmetic cosmetic ingredient functioning as Prostaglandin F2α analogue – used in eyelash growth/conditioning products. Reported NOAEL =0.0003 mg/kg bw/day in rat (Sprague-Dawley; male/female) (FDA_Toxicity_a881b3e3-f356-4118-b7ee-630b793fd47c_dossier.i6z); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 209860-87-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tafluprost is classified GHS Danger (H302, H319, H360, H370, H372, H413) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Prostaglandin F2α analogue – used in eyelash growth/conditioning products
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
InChIKey
WSNODXPBBALQOF-VEJSHDCNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA-approved as ophthalmic drug (glaucoma treatment); cosmetic use in eyelash serums occupies a regulatory grey area
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tafluprost.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Tafluprost. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0003 mg/kg bw/day | intravenous | rat (Sprague-Dawley; male/female) | reproductive toxicity | FDA_Toxicity_a881b3e3-f356-4118-b7ee-630b793fd47c_dossier.i6z |
| NOAEL | =0.0003 mg/kg bw/day | intravenous | rat (Sprague-Dawley; male/female) | reproductive toxicity | FDA_Toxicity_a881b3e3-f356-4118-b7ee-630b793fd47c_dossier.i6z |
| NOAEL | =0.0003 mg/kg bw/day | intravenous | rat (Sprague-Dawley; male/female) | reproductive toxicity | FDA_Toxicity_a881b3e3-f356-4118-b7ee-630b793fd47c_dossier.i6z |
| NOAEL | =0.0003 mg/kg bw/day | intravenous | rat (Sprague-Dawley; male/female) | reproductive toxicity | FDA_Toxicity_a881b3e3-f356-4118-b7ee-630b793fd47c_dossier.i6z |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Korea (Prohibited): Added 2024; prostaglandin analogue
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| AU | banned | - | eyelash growth |
| ASEAN | banned | - | All cosmetic products prohibited |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Tafluprost.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tafluprost by CAS number or substance name.
Studies
4
Lowest NOAEL
0.0003 mg/kg bw/day
Highest NOAEL
0.0003 mg/kg bw/day
FDA_Toxicity_a881b3e3-f356-4118-b7ee-630b793fd47c_dossier.i6z
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TAFLUPROST
ChEMBL ID
CHEMBL1963683
Max Phase
4
Adverse Event Associations
112
Frequently Asked Questions
Is Tafluprost allowed in the EU?
Tafluprost EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tafluprost do in cosmetics?
Tafluprost functions as: Prostaglandin F2α analogue – used in eyelash growth/conditioning products. It is classified as a cosmetic ingredient in our database. CAS number: 209860-87-7.
What is the NOAEL for Tafluprost?
The NOAEL (No Observed Adverse Effect Level) for Tafluprost is =0.0003 mg/kg bw/day based on a reproductive toxicity study via intravenous route in rat (Sprague-Dawley; male/female). A total of 4 study endpoints are available. Source: FDA_Toxicity_a881b3e3-f356-4118-b7ee-630b793fd47c_dossier.i6z.
Is Tafluprost used outside cosmetics?
Tafluprost also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tafluprost have different safety status in cosmetics vs industrial chemicals?
Tafluprost is classified GHS Danger (H302, H319, H360, H370, H372, H413) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tafluprost compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
1,2,4-Benzenetriacetate
Poor
Similar safety
Hair dye precursor (triacetyl ester o...
1,2,4-Trihydroxybenzene
Poor
Similar safety
Hair colorant (auto-oxidative dye)
1,4-Butanediol
Poor
Similar safety
Solvent, humectant, viscosity control...
1-Nitropropane
Poor
Similar safety
None in cosmetics - industrial solven...
2,3-Epoxypropyl Cocodimonium Chloride
Poor
Similar safety
Antistatic / hair conditioning agent ...
2,3-Epoxypropyl Lauryldimonium Chloride
Poor
Similar safety
Antistatic / hair conditioning agent ...
NORTAFLUPROST
Good
Chemical family
Hair Conditioning
TAMARINDUS INDICA FRUIT EXTRACT
Good
Browse nearby
Skin Conditioning
TARAXACUM OFFICINALE ROOT
Good
Browse nearby
Not Reported
Is Tafluprost in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tafluprost in your formulation.