Is Stannous Chloride safe in cosmetics?
Stannous Chloride has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Stannous Chloride
Also known as: Tin(II) chloride, Tin chloride (SnCl2), EINECS 231-868-0, NCI-C02722, Stannous chloride, anhydrous (+8 more)
INCI: STANNOUS CHLORIDE
Stannous Chloride (CAS 7772-99-8) is a cosmetic cosmetic ingredient functioning as Reducing agent, stabilizer, oral care ingredient (anti-caries in dentifrices). Reported NOAEL 6 mg/kg bw/day in rat (COSMOS_DB); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 7772-99-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Stannous Chloride is classified GHS Danger (H290, H302, H332, H312, H314, H317, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Reducing agent, stabilizer, oral care ingredient (anti-caries in dentifrices)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
dichlorotin
InChIKey
AXZWODMDQAVCJE-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; also approved as food additive (E 512) which supports its safety profile at low concentrations
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Stannous Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Stannous Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 6 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 16 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 20 mg/kg bw/day | oral | rabbit | Special Toxicology Study | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 32 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 41.5 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 60 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 64 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| NOAEL | 94 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Stannous chloride | TR-231: Carcinogenesis Bioassay of Stannous Chloride (CASRN 7772-99-8) in F344/N Rats and B6C3F1/N Mice (Feed Study) (1982 ) | 06/23/81 | Equivocal Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of this bioassay, stannous chloride was judged not to be carcinogenic for male or female F344/N rats or B6C3F1/N mice, although C-cell tumors of the
Source: NTP Technical Reports
ICSC Safety Card
0955
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Evaluation
TIN DICHLORIDE | 2000 | PTWI, expressed as Sn, including stannous chloride. The 1988 PTWI was not reconsidered and was maintained at the fifty-fifth meeting (2000). The acute toxicity of tin was assessed at the fifty-fifth meeting, but data were insufficient for establishing an acute reference dose. JECFA reiterated the conclusion reached in 1988 that tin concentrations as low as 150 mg/kg in cann
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Catalyst
No specific technical function
Reducing agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Stannous Chloride.
Regulatory Flags
endocrine_disruptor
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Stannous Chloride by CAS number or substance name.
Studies
27
Lowest NOAEL
6 mg/kg bw/day
Highest NOAEL
576 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
INCHEM_WHO_kemi_kemi_ah2005_07
Known Synonyms
Tin(II) chloride
Tin chloride (SnCl2)
EINECS 231-868-0
NCI-C02722
Stannous chloride, anhydrous
UNII-R30H55TN67
SnCl2
stannous chloride (anh.)
stannous chloride (anhydrous)
tin dichloride (anhydrous)
tin(II) chloride (anh.)
tin(II) chloride (anhydrous)
tin dichloride (anh.)
Chemical Function
Reducing agent
No specific technical function
Catalyst
Antioxidant
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Stannous Chloride allowed in the EU?
Stannous Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Stannous Chloride do in cosmetics?
Stannous Chloride functions as: Reducing agent, stabilizer, oral care ingredient (anti-caries in dentifrices). It is classified as a cosmetic ingredient in our database. CAS number: 7772-99-8.
What is the NOAEL for Stannous Chloride?
The NOAEL (No Observed Adverse Effect Level) for Stannous Chloride is 6 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Stannous Chloride used outside cosmetics?
Stannous Chloride also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Stannous Chloride have different safety status in cosmetics vs industrial chemicals?
Stannous Chloride is classified GHS Danger (H290, H302, H332, H312, H314, H317, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Stannous Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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