NOAEL Studies
Cosmetic Ingredient
Stannous Chloride NOAEL Studies
INCI: STANNOUS CHLORIDE
CAS: 7772-99-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 1.25 | mg/kg bw/day | mouse | oral | NA | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 6 | mg/kg bw/day | rat | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 16 | mg/kg bw/day | rat | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 20 | mg/kg bw/day | rabbit | oral | 84 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 25 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 32 | mg/kg bw/day | rat | oral | 805 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 41.5 | mg/kg bw/day | rabbit | oral | 13 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 50 | mg/kg bw/day | mouse | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 60 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 64 | mg/kg bw/day | rat | oral | 21 day | Reproductive-developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 94 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | rat | oral | 735 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 125 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 150 | mg/kg bw/day | rat | oral | 735 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 246 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 320 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 380 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2250 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3000 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 4500 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =63 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA ANS - 2018 - OutputID 3054 - body weight - systemic - Re-evaluation of stannous chloride (E 512) as food additive - doi:10.2903/j.efsa.2018.5295 |
| EFSA | NOAEL | =63 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA ANS (2018). Re-evaluation of stannous chloride (E 512) as food additive. doi:10.2903/j.efsa.2018.5295.; TITLE=Re-evaluation of stannous chloride (E 512) as food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2018.5295; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15625430:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_86e18861853d9155427bfe8d3310d925 |
WHO/JECFA 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =0.13 | mg/m3 | Human; Mouse | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=f027feec68b3370e; raw_unit=mg/m3; context=A dose of 66 ug/kg b.w./day given to mice (LOAEL) is equivalent for humans to inhalation exposure to an air concentration of 0.13 mg/m3, assuming a body weight of 70 kg, a caloric factor of 7 (52), 50% absorption in the lungs, and an inhaled air volume of 10 m3 during 8 hours. |
| WHO/JECFA | LOAEL | =0.13 | mg/m3 | Human; Mouse | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=f027feec68b3370e; raw_unit=mg/m3; context=A dose of 66 ug/kg b.w./day given to mice (LOAEL) is equivalent for humans to inhalation exposure to an air concentration of 0.13 mg/m3, assuming a body weight of 70 kg, a caloric factor of 7 (52), 50% absorption in the lungs, and an inhaled air volume of 10 m3 during 8 hours. |
| WHO/JECFA | LOAEL | =0.13 | mg/m3 | Human; Mouse | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=f027feec68b3370e; raw_unit=mg/m3; context=A dose of 66 ug/kg b.w./day given to mice (LOAEL) is equivalent for humans to inhalation exposure to an air concentration of 0.13 mg/m3, assuming a body weight of 70 kg, a caloric factor of 7 (52), 50% absorption in the lungs, and an inhaled air volume of 10 m3 during 8 hours. |
| WHO/JECFA | LOAEL | =0.13 | mg/m3 | Human; Mouse | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=f027feec68b3370e; raw_unit=mg/m3; context=A dose of 66 ug/kg b.w./day given to mice (LOAEL) is equivalent for humans to inhalation exposure to an air concentration of 0.13 mg/m3, assuming a body weight of 70 kg, a caloric factor of 7 (52), 50% absorption in the lungs, and an inhaled air volume of 10 m3 during 8 hours. |
| WHO/JECFA | LOAEL | =0.2 | mg/kg bw | Rat | subcutaneous | 21 days | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=685a16159f8593c8; raw_unit=mg/kg; context=Kavitharaj et al. (51) report a LOAEL of 0.2 mg/kg for testicular effects on male rats given s.c. injections of nicotine for 21 days. |
| WHO/JECFA | LOAEL | =0.2 | mg/kg bw | Rat | subcutaneous | 21 days | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=685a16159f8593c8; raw_unit=mg/kg; context=Kavitharaj et al. (51) report a LOAEL of 0.2 mg/kg for testicular effects on male rats given s.c. injections of nicotine for 21 days. |
| WHO/JECFA | LOAEL | =0.2 | mg/kg bw | Rat | subcutaneous | 21 days | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=685a16159f8593c8; raw_unit=mg/kg; context=Kavitharaj et al. (51) report a LOAEL of 0.2 mg/kg for testicular effects on male rats given s.c. injections of nicotine for 21 days. |
| WHO/JECFA | LOAEL | =0.2 | mg/kg bw | Rat | subcutaneous | 21 days | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=685a16159f8593c8; raw_unit=mg/kg; context=Kavitharaj et al. (51) report a LOAEL of 0.2 mg/kg for testicular effects on male rats given s.c. injections of nicotine for 21 days. |
| WHO/JECFA | NOAEL | =0.014 | mg/m3 | - | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=33a1f0aa2e84e9ff; raw_unit=mg/m3; context=Using the same calculation for a dose of 7 ug/kg (the NOAEL) yields an air concentration of 0.014 mg/m3. |
| WHO/JECFA | NOAEL | =0.014 | mg/m3 | - | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=33a1f0aa2e84e9ff; raw_unit=mg/m3; context=Using the same calculation for a dose of 7 ug/kg (the NOAEL) yields an air concentration of 0.014 mg/m3. |
| WHO/JECFA | NOAEL | =0.014 | mg/m3 | - | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=33a1f0aa2e84e9ff; raw_unit=mg/m3; context=Using the same calculation for a dose of 7 ug/kg (the NOAEL) yields an air concentration of 0.014 mg/m3. |
| WHO/JECFA | NOAEL | =0.014 | mg/m3 | - | inhalation | - | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=33a1f0aa2e84e9ff; raw_unit=mg/m3; context=Using the same calculation for a dose of 7 ug/kg (the NOAEL) yields an air concentration of 0.014 mg/m3. |
| WHO/JECFA | NOAEL | =32.1428571428571 | mg/kg bw/day | Mouse | - | 5 days | Subchronic toxicity | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=58cdaff0d3502063; raw_unit=mg/kg bw/day; unit_normalization=converted from weekly dose; context=Mouse NOAEL 21 225 mg/kg bw/day 5 days/week, 13 weeks, p.o. |
| WHO/JECFA | NOAEL | =32.1428571428571 | mg/kg bw/day | Mouse | - | 5 days | Subchronic toxicity | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=58cdaff0d3502063; raw_unit=mg/kg bw/day; unit_normalization=converted from weekly dose; context=Mouse NOAEL 21 225 mg/kg bw/day 5 days/week, 13 weeks, p.o. |
| WHO/JECFA | NOAEL | =32.1428571428571 | mg/kg bw/day | Mouse | - | 5 days | Subchronic toxicity | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=58cdaff0d3502063; raw_unit=mg/kg bw/day; unit_normalization=converted from weekly dose; context=Mouse NOAEL 21 225 mg/kg bw/day 5 days/week, 13 weeks, p.o. |
| WHO/JECFA | NOAEL | =32.1428571428571 | mg/kg bw/day | Mouse | - | 5 days | Subchronic toxicity | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=58cdaff0d3502063; raw_unit=mg/kg bw/day; unit_normalization=converted from weekly dose; context=Mouse NOAEL 21 225 mg/kg bw/day 5 days/week, 13 weeks, p.o. |
| WHO/JECFA | NOAEL | =350 | mg/kg bw/day | Rat | - | 12 days | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=f600de0fff806a0b; raw_unit=mg/kg bw/day; context=Rat NOAEL 21 350 mg/kg bw/day 12 days, p.o. |
| WHO/JECFA | NOAEL | =350 | mg/kg bw/day | Rat | - | 12 days | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=f600de0fff806a0b; raw_unit=mg/kg bw/day; context=Rat NOAEL 21 350 mg/kg bw/day 12 days, p.o. |
| WHO/JECFA | NOAEL | =350 | mg/kg bw/day | Rat | - | 12 days | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=f600de0fff806a0b; raw_unit=mg/kg bw/day; context=Rat NOAEL 21 350 mg/kg bw/day 12 days, p.o. |
| WHO/JECFA | NOAEL | =350 | mg/kg bw/day | Rat | - | 12 days | Toxicology study | document_id=kemi_kemi_ah2005_07; title=Scientific Basis for Swedish Occupational Standards XXV; path=mirror/documents/kemi/kemi/ah2005_07.pdf; row_hash=f600de0fff806a0b; raw_unit=mg/kg bw/day; context=Rat NOAEL 21 350 mg/kg bw/day 12 days, p.o. |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 2000 | ppm | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=8980; Record_ID=cancer_3958; Data_Type=In Vivo; Formulation_Name=Stannous chloride; Mixture=Chemical; DTXSID=DTXSID8021351; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Reference=TR-231; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr231/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021351; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021351 |
ECHA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | >50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac7be4b0a7c65d1bf48f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11280/7/9/3?documentUUID=d16ab57d-6c45-453a-aab7-0f5c408111cb; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15825225:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e1006dffa67376269388da0ace66b9a7 |
| ECHA | NOAEL | =240 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d87; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15968/7/10/2?documentUUID=3716fb40-6ed8-4237-871d-00f03b67b1a6; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15825535:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2c35e3595d71dc20721ef1816d78753f |
| ECHA | NOAEL | =576 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d87; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15968/7/10/2?documentUUID=3716fb40-6ed8-4237-871d-00f03b67b1a6; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=immunology; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID:15825534:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aa4d5a5861e129c531b83c4aca7e8641 |
ToxValDB ECOTOX 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =250 | umol/kg bw | Rat | injection | short-term; 3 days | short-term | LONG_REF=Pharmacology38(3): 159-166 Rosenberg,D.W., and A. Kappas Comparative Ability of Exogenously Administered Metals to Alter Tissue Levels and Urinary Output of Copper and Zinc 1989; TITLE=Comparative Ability of Exogenously Administered Metals to Alter Tissue Levels and Urinary Output of Copper and Zinc; AUTHOR=Rosenberg,D.W., and A. Kappas; DOI=10.1159/000138533; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101259; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: Copper (Cu) content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595222_15601178:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=29d917c80fe169d8a4e86e627855c81a |
| ToxValDB ECOTOX | NOEL | =0.28 | ug/g wet wt diet | Mouse | oral | chronic; 129 days | chronic | LONG_REF=J. Nutr.92:245-252 Schroeder,H.A., and J.J. Balassa Arsenic, Germanium, Tin and Vanadium in Mice: Effects on Growth, Survival and Tissue Levels 1967; TITLE=Arsenic, Germanium, Tin and Vanadium in Mice: Effects on Growth, Survival and Tissue Levels; AUTHOR=Schroeder,H.A., and J.J. Balassa; DOI=10.1093/jn/92.2.245; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=70293; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1967; ORIGINAL_YEAR=1967; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15594210:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3575abdeccefaabf88b4e30b20b36efb |
| ToxValDB ECOTOX | NOEL | =200 | mg/kg bw/day | European Rabbit | oral | acute; 1 days | acute | LONG_REF=- | Ecotoxicol. Environ. Saf.24(3): 266-274 Chmielnicka,J., G. Zareba, and U. Grabowska Protective Effect of Zinc on Heme Biosynthesis Disturbances in Rabbits after Administration Per Os of Tin 1992; TITLE=Protective Effect of Zinc on Heme Biosynthesis Disturbances in Rabbits after Administration Per Os of Tin; AUTHOR=Chmielnicka,J., G. Zareba, and U. Grabowska; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85899; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Biochemistry: ALA-D and ALA-U activity, FEP concentrations; STUDY_GROUP=ECOTOX:15613532:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=9606c9600577c83185c229779bdb3500 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635259:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6295a3db2a34807118a6db10ca6d5660 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | =364.8 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e0fe4b0a676289df448; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Body Weight Changes: decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=HESS:15638699:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f0c757699f628cd3baa5120238e75a6e |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | R30H55TN67 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2Cl.Sn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R30H55TN67"} |
| openFDA substances | FDA UNII substance identifier | R30H55TN67 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2Cl.Sn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R30H55TN67"} |
| openFDA substances | FDA UNII substance identifier | R30H55TN67 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2Cl.Sn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R30H55TN67"} |
| openFDA substances | FDA UNII substance identifier | R30H55TN67 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2Cl.Sn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R30H55TN67"} |