Is Sodium Thiosulfate safe in cosmetics?
Sodium Thiosulfate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Sodium Thiosulfate
Also known as: EINECS 231-867-5, Hypo (VAN), NSC 45624, UNII-L0IYT1O31N, Sodium hyposulfite (+2 more)
INCI: SODIUM THIOSULFATE
Sodium Thiosulfate (CAS 7772-98-7) is a cosmetic cosmetic ingredient functioning as Reducing agent, antioxidant, neutralizer (used post-perming to stop thiol. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7772-98-7 →
Auto-generated CPSR Part A draft with source citations
Function
Reducing agent, antioxidant, neutralizer (used post-perming to stop thiol reactions)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
disodium;dioxido-oxo-sulfanylidene-lambda6-sulfane
InChIKey
AKHNMLFCWUSKQB-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; also has pharmaceutical monograph (USP) as antidote agent
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Thiosulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1138
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (1)
JECFA Evaluation
SODIUM THIOSULFATE | 1998 | 0-0.7 mg/kg bw | Group ADI, expressed as sulfur dioxide, for calcium hydrogen sulfite, calcium metabisulfite, calcium sulfite, potassium hydrogen sulfite, potassium metabisulfite, potassium sulfite, sodium hydrogen sulfite, sodium metabisulfite, sodium sulfite, sodium thiosulfate, and sulfur dioxide | TRS 891-JECFA 51/30 | FAS 42-JECFA 51/95
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Chelating agent
Fragrance
No specific technical function
Oxidizing agent
Processing aids not otherwise specified
Reducing agent
Stabilizing agent
Thickening agent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Thiosulfate.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
EINECS 231-867-5
Hypo (VAN)
NSC 45624
UNII-L0IYT1O31N
Sodium hyposulfite
anhydrous sodium thiosulfate
sodium thiosulfate (anhydrous)
Chemical Function
Reducing agent
No specific technical function
Fragrance
Processing aids not otherwise specified
Stabilizing agent
Regulatory Lists
inert_ingredient; Pesticides
pharmaceutical
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
fracking; water
active_ingredient; animal_products; Europe; pharmaceutical; residue
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3753202
Adverse Event Associations
50
Frequently Asked Questions
Is Sodium Thiosulfate allowed in the EU?
Sodium Thiosulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Thiosulfate do in cosmetics?
Sodium Thiosulfate functions as: Reducing agent, antioxidant, neutralizer (used post-perming to stop thiol reactions). It is classified as a cosmetic ingredient in our database. CAS number: 7772-98-7.
Is Sodium Thiosulfate used outside cosmetics?
Sodium Thiosulfate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Thiosulfate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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