Is Sodium Riboflavin Phosphate safe in cosmetics?
Sodium Riboflavin Phosphate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Sodium Riboflavin Phosphate
INCI: SODIUM RIBOFLAVIN PHOSPHATE
Sodium Riboflavin Phosphate (CAS 130-40-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning (skin protectant). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 130-40-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (skin protectant)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
sodium [(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate
InChIKey
OHSHFZJLPYLRIP-BMZHGHOISA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; also has GRAS status as a nutrient (vitamin B2 derivative). CIR reviewed and concluded safe as used (2023 final report)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Riboflavin Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
VITAMIN B2 PHOSPHATE ESTER MONOSODIUM SALT | 2021 | NOT SPECIFIED | JECFA established a group ADI “not specified” for riboflavin, riboflavin- 5´-phosphate, riboflavin from B. subtilis and riboflavin from A. gossypii, expressed as riboflavin. JECFA withdrew the previous group ADI of 0–0.5 mg/kg bw. | TRS 1037-JECFA 92/28 | FAS 83-JECFA 92/85
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Riboflavin Phosphate.
Regulatory Flags
fda_food_additive
Chemical Function
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
RIBOFLAVIN 5'-PHOSPHATE
ChEMBL ID
CHEMBL1201794
Max Phase
4
Adverse Event Associations
446
Frequently Asked Questions
Is Sodium Riboflavin Phosphate allowed in the EU?
Sodium Riboflavin Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Riboflavin Phosphate do in cosmetics?
Sodium Riboflavin Phosphate functions as: Skin conditioning (skin protectant). It is classified as a cosmetic ingredient in our database. CAS number: 130-40-5.
Is Sodium Riboflavin Phosphate used outside cosmetics?
Sodium Riboflavin Phosphate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Riboflavin Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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